An experimental Staphylococcus aureus meningitis model for investigating induced leptomeningeal and subpial inflammation in rats: A transmission electron microscopy study

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dc.contributor.authorGuzel A.
dc.contributor.authorEr U.
dc.contributor.authorTatli M.
dc.contributor.authorAluclu U.
dc.contributor.authorOzekinci T.
dc.contributor.authorNergiz Y.
dc.contributor.authorAhishali B.
dc.date.accessioned2024-04-24T18:45:41Z
dc.date.available2024-04-24T18:45:41Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: To evaluate leptomeningeal and subpial inflammatory responses of experimental Staphylococcus aureus bacteriemia following intraperitoneal and intravenous applications and to compare the inflammatory reactions in different regions of central nervous-system. Material and Methods: Forty anesthetized rats were divided into four groups equal in number. The rats in group-I were given 1 ml suspension of Staphylococcus aureus intraperitoneally. Group-II was the control group of group I; it was administrated 1 ml 0.9% NaCl in water intraperitoneally. The rats in group-III were given the same amount of bacteria intravenously. Group IV was the control group of the group-III; it was administrated 1 ml 0.9% NaCl solution intravenously. The rats were sacrificed on the 21st day. Inflammatory changes of different regions of the central nervous system were examined under transmission electron microscopy. Statistical analysis was done by using variance analysis, Bonferroni, Tamhane post hoc, Student's t and univariate tests. Results: Thoracic and occipital regions were the most vulnerable zones. Increasing of collagen tissue was the most detected inflammatory change. Conclusion: This experimental model can be used for inducing subpial and leptomeningeal inflammations and it may be developed for investigations of pathogenesis of leptomeningitis during systemic infections. © 2007 Neuroendocrinology Letters.en_US
dc.identifier.endpage658en_US
dc.identifier.issn0172-780X
dc.identifier.issue5en_US
dc.identifier.pmid17984956
dc.identifier.scopus2-s2.0-38049034895
dc.identifier.scopusqualityQ3
dc.identifier.startpage652en_US
dc.identifier.urihttps://hdl.handle.net/11468/24791
dc.identifier.volume28en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMaghira and Maas Publicationsen_US
dc.relation.ispartofNeuroendocrinology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectron Microscopyen_US
dc.subjectInflammatory Reactionsen_US
dc.subjectMeningitis Modelen_US
dc.subjectStaphylococcus Aureusen_US
dc.titleAn experimental Staphylococcus aureus meningitis model for investigating induced leptomeningeal and subpial inflammation in rats: A transmission electron microscopy studyen_US
dc.titleAn experimental Staphylococcus aureus meningitis model for investigating induced leptomeningeal and subpial inflammation in rats: A transmission electron microscopy study
dc.typeArticleen_US

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