Exploring 18 F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditions

Basit Öğe Kaydı
dc.contributor.authorTuzcu, Sadiye Altun
dc.contributor.authorCetinkaya, Erdal
dc.contributor.authorGuzel, Fatih
dc.contributor.authorCetin, lbey Erkin
dc.contributor.authorMete, Umit
dc.contributor.authorArgin, Esref
dc.contributor.authorTasdemir, Bekir
dc.date.accessioned2025-02-22T14:09:12Z
dc.date.available2025-02-22T14:09:12Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study aimed to explore the relationship between fluorine-18-fluorodeoxyglucose (F-18-FDG) uptake in the liver, spleen, and bone marrow and inflammatory markers such as c-reactive protein (CRP), albumin, and erythrocyte sedimentation rate (ESR) in patients undergoing positron emission tomography/computed tomography (PET/CT) imaging for cancer diagnosis. Subjects and methods: This retrospective cross-sectional study included a total of 708 patients with a diagnosis of malignancy. Fluorine-18-FDG PET/CT images acquired between January 2021 and December 2022. Exclusion criteria comprised prior chemotherapy, radiotherapy, hematological malignancies, or liver/spleen tumors. Statistical analysis included correlation analysis, univariate, and multivariate regression analysis. Results: C-reactive protein levels demonstrated a significant positive correlation with F-18-FDG uptake in the spleen (r=0.104, P=0.006) and bone marrow (r=0.112, P=0.003). Albumin showed a negative correlation with liver F-18-FDG uptake (r=-0.220, P<0.001). Regression analysis revealed ESR's impact on spleen-to-liver (P=0.023) and bone marrow-to-liver (P=0.012) F-18-FDG uptake. Conclusion: This study demonstrates the association between inflammatory markers and F-18-FDG uptake in liver, spleen and bone marrow. C-reactive protein and ESR showing significant correlations with spleen and bone marrow F-18-FDG uptake, and albumin correlated with liver F-18-FDG uptake negatively. Erythrocyte sedimentation rate had significant impact on spleen and bone marrow F-18-FDG uptakes. These findings suggest the potential of F-18-FDG PET/CT in diagnosing inflammatory conditions, warranting further investigation into its clinical implications.en_US
dc.identifier.endpage187en_US
dc.identifier.issn1108-1430
dc.identifier.issn1790-5427
dc.identifier.issue3en_US
dc.identifier.pmid39644269en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://hdl.handle.net/11468/29829
dc.identifier.volume27en_US
dc.identifier.wosWOS:001408474000004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHellenic Soc Nuclear Medicineen_US
dc.relation.ispartofHellenic Journal of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectInflammatory markersen_US
dc.subjectC-reactive protein- Albuminen_US
dc.subjectErythrocyte sedimentation rateen_US
dc.subject(18)-FDG PET/CTen_US
dc.titleExploring 18 F-FDG uptake patterns in liver, spleen, and bone marrow: Implications for inflammatory and infectious conditionsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu