Gold nanoparticle loaded phytosomal systems: synthesis, characterization and in vitro investigations

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dc.contributor.authorDemir, B.
dc.contributor.authorBarlas, F. B.
dc.contributor.authorGuler, E.
dc.contributor.authorGumus, P. Z.
dc.contributor.authorCan, M.
dc.contributor.authorYavuz, M.
dc.contributor.authorCoskunol, H.
dc.date.accessioned2024-04-24T16:24:05Z
dc.date.available2024-04-24T16:24:05Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractMost medicinal and pharmaceutical herbal extracts are poorly soluble in aqueous moieties and have reduced adsorption by living cells. Liposomal encapsulation of those so called phytosomes could be a solution to overcome this problem. Meanwhile, much research shows that metallic nanoparticles such as gold nanoparticles ( AuNPs) exhibit biological activity such as wound healing and antioxidant properties on living cells. Here, we constructed a novel liposomal formulation by encapsulating both Calendula officinalis extract and AuNPs. After the preparation of vesicles using the traditional thin film hydration method within extrusion, the resulting AuNP-phytosomes were characterized by dynamic light scattering size measurements, zeta potential and atomic force microscopy. These vesicles are less than 100 nm in size and have a high encapsulation efficiency for chlorogenic acid and quercetin as the model major molecules of Calendula extract. Furthermore, AuNP-phytosomes exhibited antioxidant and wound healing activity significantly according to the free forms of each encapsulated material and the plain liposome as well as the phytosome form. Moreover, the cellular interactions of the vesicles were monitored using the nano-vesicles prepared by Texas-Red labelled lipids under fluorescence microscopy.en_US
dc.description.sponsorshipIndustrial thesis support program (SANTEZ) by Ministry of Science, Industry and Technology [0395.STZ.2013-2]; Ege University Scientific Research Project [2013/FEN/024]; Ege University Aliye Uster Foundationen_US
dc.description.sponsorshipThis study was funded by Industrial thesis support program (SANTEZ) by Ministry of Science, Industry and Technology (0395.STZ.2013-2). And also this work was partially supported by Ege University Scientific Research Project (2013/FEN/024). Ege University Aliye Uster Foundation was also acknowledged for the research grants. Authors were grateful to WATERS Corp. for supplying UPLC system.en_US
dc.identifier.doi10.1039/c4ra05108d
dc.identifier.endpage34695en_US
dc.identifier.issn2046-2069
dc.identifier.issue65en_US
dc.identifier.scopus2-s2.0-84906278311
dc.identifier.scopusqualityQ1
dc.identifier.startpage34687en_US
dc.identifier.urihttps://doi.org/10.1039/c4ra05108d
dc.identifier.urihttps://hdl.handle.net/11468/16469
dc.identifier.volume4en_US
dc.identifier.wosWOS:000341287500064
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofRsc Advances
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleGold nanoparticle loaded phytosomal systems: synthesis, characterization and in vitro investigationsen_US
dc.titleGold nanoparticle loaded phytosomal systems: synthesis, characterization and in vitro investigations
dc.typeArticleen_US

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