Effects of induced pressure and clamping force by vascular clamps on the vascular endothelium of rat aorta

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dc.contributor.authorTezcan, Orhan
dc.contributor.authorBasyigit, Ismail
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorEkinci, Cenap
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorYavuz, Celal
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:28:01Z
dc.date.available2024-04-24T17:28:01Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: This study aims to investigate the effects of vascular clamps on the vascular endothelium of rat aorta. Methods: The study included 32 male Sprague-Dawley rats (weight 242 +/- 26 g; age 9 to 11 weeks). Rats were divided into four equal groups: control group: no clamp was applied on abdominal aorta; group 1: plastic bulldog clamp was applied on abdominal aorta for 10 minutes; group 2: metal bulldog clamp was applied on abdominal aorta for 10 minutes; group 3: microvascular clamp was applied on abdominal aorta for 10 minutes. At the end of 10 minutes, segments occluded with vascular clamp were excised in all groups and endothelial structures were evaluated histopathologically. Results: Normal cellular sequencing and structure were determined in control group. Most severe injury of the endothelial surface was observed in group 3, moderate level endothelial injury was observed in group 2, while mildest endothelial injury was observed in group 1. Increased vascular endothelial growth factor expression levels were detected histopathologically in groups 1 and 2 (2.8 +/- 0.5 and 3.3 +/- 0.5, respectively) when compared with the control subjects (2.0 +/- 0.5). Conclusion: Due to their induced pressure and clamping force, vascular clamps may cause endothelial injury.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2016.12565
dc.identifier.endpage735en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.startpage729en_US
dc.identifier.trdizinid219535
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2016.12565
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/219535
dc.identifier.urihttps://hdl.handle.net/11468/20293
dc.identifier.volume24en_US
dc.identifier.wosWOS:000388114100018
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndothelial Injuryen_US
dc.subjectHistopathologyen_US
dc.subjectVascular Clampsen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.titleEffects of induced pressure and clamping force by vascular clamps on the vascular endothelium of rat aortaen_US
dc.titleEffects of induced pressure and clamping force by vascular clamps on the vascular endothelium of rat aorta
dc.typeArticleen_US

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