Preparation, characterization and drug release of chitosan hydrogels derived from substituted salicylaldehyde

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dc.authorid0000-0002-9833-3633en_US
dc.contributor.authorEvcil, Murat
dc.contributor.authorKarakaplan, Mehmet
dc.date.accessioned2023-10-23T12:08:54Z
dc.date.available2023-10-23T12:08:54Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Kimya Bölümüen_US
dc.description.abstractChitosan-based hydrogels (CSAD1, CSAD2 and CSAD3) have been successfully prepared by dynamic imine reaction between chitosan and varying ratios of 2-[(2,3-dihydroxy)-1-propoxy]benzaldehyde (SAD) as a linker group respectively. SAD was synthesized from salicylaldehyde and glycidol by atom economy method. FT-IR and NMR data were used to determine the SAD and hydrogels’ structures. The fabricated hydrogels exhibit a porous structure that the pore size decreased with increasing ratio of SAD group. Hydrogels were swelled in aqueous media but not soluble in both acidic and alkaline medium. The highest swelling capacity was obtained at pH 7 with the order of CSAD1, CSAD2, and CSAD3, respectively. The high thermal behavior of the hydrogels was tested by thermal gravimetric analysis (TGA) and differential scanning calorimetry (DSC). Ibuprofen was selected as a model drug for the drug release behaviors of the hydrogels. Release of ibuprofen is influenced by the pore sizes of the hydrogels in order of CSAD1, CSAD2, and CSAD3, respectively.en_US
dc.identifier.citationEvcil, M. ve Karakaplan, M. (2023). Preparation, characterization and drug release of chitosan hydrogels derived from substituted salicylaldehyde. ChemistrySelect, 8(12), 1-6.en_US
dc.identifier.doi10.1002/slct.202204426
dc.identifier.endpage6en_US
dc.identifier.issn2365-6549
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85151079899
dc.identifier.scopusqualityQ3
dc.identifier.startpage1en_US
dc.identifier.urihttps://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.202204426
dc.identifier.urihttps://hdl.handle.net/11468/12903
dc.identifier.volume8en_US
dc.identifier.wosWOS:001061338500041
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEvcil, Murat
dc.institutionauthorKarakaplan, Mehmet
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofChemistrySelect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChitosanen_US
dc.subjectDrug deliveryen_US
dc.subjectHydrogelsen_US
dc.subjectSalicylaldehydeen_US
dc.subjectSchiff basesen_US
dc.subjectSwellingen_US
dc.titlePreparation, characterization and drug release of chitosan hydrogels derived from substituted salicylaldehydeen_US
dc.titlePreparation, characterization and drug release of chitosan hydrogels derived from substituted salicylaldehyde
dc.typeArticleen_US

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