Homeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery

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dc.contributor.authorAşır F.
dc.contributor.authorOğlak S.C.
dc.contributor.authorAğaçayak E.
dc.contributor.authorAlabalık U.
dc.date.accessioned2024-04-24T17:58:30Z
dc.date.available2024-04-24T17:58:30Z
dc.date.issued2023
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate Homeobox A Cluster 7 (HOXA7) protein expression in the placentas of patients with preterm labor by immunohistochemical method. Methods: Placentas of 25 healthy women with term delivery and 25 women with preterm delivery were enrolled in this study. Placental samples were fixed in zinc-formalin and further processed for paraffin wax tissue embedding. Demographic and laboratory parameters of patients were recorded. HOXA7 immune activity was analyzed in the placental section with immunohistochemistry. Results: In the placentas in the term delivery group, normal histology was observed with no placental lesions. In placentas in the preterm delivery group, degenerated villi, fibrin deposition, and cytotrophoblast delamination with vascular congestion were recorded. HOXA7 protein expression was very high in preterm placentas compared to term placentas. The expression was obvious, especially in cytotrophoblast cells and villous connective tissue. Conclusion: HOXA gene family is required for proper placental formation. HOXA7 protein expression may be differently regulated in preterm placentas and may be involved in the pathogenesis of preterm delivery. © 2023 Perinatal Medicine Foundation.en_US
dc.identifier.doi10.59215/prn.23.0313006
dc.identifier.endpage218en_US
dc.identifier.issn1305-3124
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85188987577
dc.identifier.scopusqualityQ4
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.59215/prn.23.0313006
dc.identifier.urihttps://hdl.handle.net/11468/23954
dc.identifier.volume31en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPerinatal Medicine Foundationen_US
dc.relation.ispartofPerinatal Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHox Genesen_US
dc.subjectPlacentaen_US
dc.subjectPreterm Deliveryen_US
dc.titleHomeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm deliveryen_US
dc.titleHomeobox A Cluster 7 (HOXA7) protein expression increased in the placentas of patients with preterm delivery
dc.typeArticleen_US

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