Nizip Yaglık olive leaves (Olea europaea L.) collected at different seasons and altitudes: Enzyme inhibition, antioxidant activities and phenolic compound profiles

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0001-7213-3601en_US
dc.contributor.authorKaygısız, Feyza
dc.contributor.authorKaya, Elife
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.date.accessioned2025-02-20T11:56:12Z
dc.date.available2025-02-20T11:56:12Z
dc.date.issued2024en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThis study aimed to evaluate the antioxidant activity (DPPH, ABTS, CUPRAC, and iron-reducing power methods) phenolic component profiles (by LC-MS/MS), and cholinesterase enzyme inhibition of Nizip Yaglık olive leaf extracts. The leaves were collected from the Nizip district of Gaziantep province at three different altitudes and during four different seasons. The winter season Kocatepe location extract (W3), at a concentration of 160 μg/mL, demonstrated the highest antioxidant activity among all olive leaf extracts. The major components identified by LC-MS/MS analysis were cynaroside (luteolin-7-glucoside) and quinic acid among fifty-three components, with the highest concentration found in the summer season Kocatepe location extract (SU3, 18.986 mg/g) and the autumn season Kerzin location extract (A1, 14.147 mg/g) respectively. Fingerprint phytochemical analysis was also performed for four compounds (3-hydroxytyrosol, oleuropein, diosmin, verbascoside) on the extracts. Oleuropein and verbascoside were determined as 56.738 mg/g in the winter season Kocatepe location (W3) extract and 8.853 mg/g in the spring season Kerzin location (S1) extract, respectively. The spring season İkizce location extract (S2, IC50: 10.16 μg/mL) exhibited the strongest inhibition on the AChE enzyme, while the spring season Kocatepe location extract (S3, IC50: 7.73 μg/mL) exhibited the highest inhibition on the BChE enzyme. The study concluded that olive leaves have increased antioxidant and enzyme inhibition potential, especially when harvested in the winter and spring seasons and at higher altitudes. These findings suggested that Nizip Yaglık olive leaves could be valuable for therapeutic drug production and pharmacological research due to their rich phenolic content and high antioxidant activity.en_US
dc.identifier.citationKaygısız, F., Kaya, E. ve Yılmaz, M. A. (2024). Nizip Yaglık olive leaves (Olea europaea L.) collected at different seasons and altitudes: Enzyme inhibition, antioxidant activities and phenolic compound profiles. Food Bioscience, 62, 1-9.en_US
dc.identifier.endpage10en_US
dc.identifier.issn2212-4292
dc.identifier.scopus2-s2.0-85209921126en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2212429224019552?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/29477
dc.identifier.volume62en_US
dc.identifier.wosWOS:001366621300001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Science
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofFood Bioscienceen_US
dc.relation.isversionof10.1016/j.fbio.2024.105524en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant activityen_US
dc.subjectCholinesteraseen_US
dc.subjectLC-MS/MSen_US
dc.subjectNizip Yaglık olive leafen_US
dc.titleNizip Yaglık olive leaves (Olea europaea L.) collected at different seasons and altitudes: Enzyme inhibition, antioxidant activities and phenolic compound profilesen_US
dc.typeArticleen_US

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