Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey

Basit Öğe Kaydı
dc.contributor.authorÇiçek, Ayşegül Çopur
dc.contributor.authorDüzgün, Azer Özad
dc.contributor.authorSaral, Ayşegül
dc.contributor.authorKayman, Tuba
dc.contributor.authorÇIzmecI, Zeynep
dc.contributor.authorBalcı, Pervin Özlem
dc.contributor.authorDal, Tuba
dc.contributor.orcid0000-0002-3673-9670
dc.date.accessioned2024-04-24T17:56:12Z
dc.date.available2024-04-24T17:56:12Z
dc.date.issued2013
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: To investigate the antibiotic resistance genes inserted into class 1 and class 2 integrons in Acinetobacter baumannii (A. baumannii) isolates obtained from nine different cities in Turkey. Methods: A collection of 281 A. baumannii clinical isolates were collected from nine diferent state hospitals in Turkey and were confirmed as A. baumannii by conventional biochemical, API testing and bla-OXA-51 specific PCR. The isolates were examined by PCR for existence of class 1 and 2 integron gene cassettes. Results: They were characterized by antimicrobial susceptibility testing and the highest resistance rates were determined for piperacillin (90.03%), ciprofloxacin (87.54%), cefepime and trimethoprim/sulfamethoxazole (81.13%). The lowest resistance rates was for cefotaxime (3.55%). class I integrons were detected in 6.4% (18/281) of A. baumannii strains and no class 2 integron was detected. The gene cassettes of class 1 integrons AacC1-AAC(3) I-aadA1, AacC1-aadA1, AAC(3)-I, AAC(3)-I -AAC(3)-I -aadA1, TEM-1, AAC(3)-I-aadA1 - AAC(3)-I -AAC(3)-I, AAC(3)-I -AAC(3)-I -AAC(3)-I -aadA1, AAC(3)-I - aadA1, AAC(3)-I-AAC(3)-I, AAC(3)-I-aadA1-AAC(3)-I-aadA1, AAC(3)-I-AAC(3)-I-aadA1-AAC(3)-I-aadA1 were detected in eighteen strains. The aac genes family were most frequently found integrated into the class 1 integrons and it was followed by aadA genes and TEM-1 genes. Conclusions: This is an extensive study on the distribution of class 1 integron among A. baumannii in Turkey. In addition to these, two new alleles were observed. Their percentage rates of similarity to other cassettes are 95% aadA1 (TKA18) and 89% aadA1 (ANKA3).en_US
dc.identifier.citationÇiçek, A. Ç., Düzgün, A. Ö., Saral, A., Kayman, T., ÇIzmecI, Z., Balcı, P. Ö. ve diğerleri. (2013). Detection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey. Asian Pacific Journal of Tropical Biomedicine, 3(9), 743-747.
dc.identifier.doi10.1016/S2221-1691(13)60149-5
dc.identifier.endpage747en_US
dc.identifier.issn2221-1691
dc.identifier.issue9en_US
dc.identifier.pmid23998017
dc.identifier.scopus2-s2.0-84883257201
dc.identifier.scopusqualityQ2
dc.identifier.startpage743en_US
dc.identifier.urihttps://doi.org/10.1016/S2221-1691(13)60149-5
dc.identifier.urihttps://hdl.handle.net/11468/23362
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S2221169113601495
dc.identifier.volume3en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectClass 1 integronen_US
dc.subjectGene cassetteen_US
dc.subjectResistanceen_US
dc.titleDetection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkeyen_US
dc.titleDetection of class 1 integron in Acinetobacter baumannii isolates collected from nine hospitals in Turkey
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu