Does Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?

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dc.contributor.authorAkdag, Mehmet
dc.contributor.authorDasdag, Suleyman
dc.contributor.authorAlabalik, Ulas
dc.contributor.authorYilmaz, Beyhan
dc.contributor.authorAltas, Sevcan
dc.contributor.authorZincircioglu, Seyit Burhanedtin
dc.contributor.authorGul, Aylin
dc.date.accessioned2024-04-24T17:27:27Z
dc.date.available2024-04-24T17:27:27Z
dc.date.issued2014
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of this study was to investigate the protective effect of short-term usage of fresh pomegranate juice (FPJ) on ototoxicity after cisplatin-based chemo-irradiation. MATERIALS and METHODS: The study was carried out on 56 adult Wistar Albino rats, which were divided into 8 groups (n: 7 for each group). The first group was accepted as the sham control group. However, rats in the seven experimental groups were treated with FPJ; cisplatin; irradiation; irradiation plus FPJ; cisplatin plus FPJ; both cisplatin and irradiation; and combined use of cisplatin, irradiation, and FPJ, respectively. Ototoxicity was evaluated by Distortion Product Otoacoustic Emissions (DPOA), histopathology, and paracochlear protein carbonyl content. RESULTS: The results of the study showed that cisplatin, irradiation, and both cisplatin and irradiation treatments affected hair cells dramatically. However, the results of cisplatin plus FPJ and combined use of cisplatin, irradiation, and FPJ indicated that FPJ plays an important role in protecting hair cells in the inner ear. Additionally, the findings of signal-noise ratio and protein carbonyl values also supported the results stated above. CONCLUSION: Fresh pomegranate juice treatment can be a supportive agent to reduce hair cell injury in the inner ear of patient treated by cisplatin, radiotherapy, or cisplatin-based chemo-irradiation. However, more performance is necessary for further studies, especially on long-term treatment with FPJ.en_US
dc.description.sponsorshipDicle University Scientific Found (DUBAP) [13-TF-94]en_US
dc.description.sponsorshipThis study was supported by Dicle University Scientific Found (DUBAP, project number13-TF-94)en_US
dc.identifier.doi10.5152/iao.2014.72
dc.identifier.endpage133en_US
dc.identifier.issn1308-7649
dc.identifier.issn2148-3817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85002157011
dc.identifier.scopusqualityQ3
dc.identifier.startpage128en_US
dc.identifier.urihttps://doi.org/10.5152/iao.2014.72
dc.identifier.urihttps://hdl.handle.net/11468/19949
dc.identifier.volume10en_US
dc.identifier.wosWOS:000346138500006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofJournal of International Advanced Otology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPomegranateen_US
dc.subjectIrradiationen_US
dc.subjectCisplatin-Based Chemo-Irradiationen_US
dc.subjectHair Cells Of Inner Earen_US
dc.subjectOtotoxicityen_US
dc.subjectOxidative Stressen_US
dc.subjectProtein Oxidationen_US
dc.titleDoes Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?en_US
dc.titleDoes Short Term Usage of Fresh Pomegranate Juice (FPJ) Protect Cochlear Hair Cells after Cisplatin-Based Chemo-Irradiation?
dc.typeArticleen_US

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