Effect of vitamin D3 and a stinging nettle extract on the gastric tissue of rats administered with trinitrobenzene sulfonic acid

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dc.contributor.authorGezer, Arzu
dc.contributor.authorAras, Sukran Yediel
dc.contributor.authorBaygutalp, Nurcan Kilic
dc.contributor.authorSari, Ebru Karadag
dc.contributor.authorBedir, Gursel
dc.contributor.authorMokhtare, Behzad
dc.contributor.authorYilmaz, Kadriye
dc.date.accessioned2024-04-24T17:18:15Z
dc.date.available2024-04-24T17:18:15Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn this study, the effects of vitamin D-3 (Vit. D) and a stinging nettle [Urtica dioica L. (UD)] extract were examined using histopathological and immunohistochemical methods in the stomach tissues of an experimentally created rat model of Crohn's disease (CD). The CD model was created using trinitrobenzene sulfonic acid (TNBS). The animals in the study were divided into control, TNBS, TNBS+Vit. D, and TNBS+UD groups. At the end of the experiment, the animals were euthanised and their stomach tissues were evaluated for necrosis, degeneration, apoptosis, and inflammation. Additionally, an immunohistochemical method was applied to determine the somatostatin (SSTR), aquaporin-1 (AQP-1), caspase-3, and tumour necrosis factor-alpha (TNF-a) immunoreactivity in the gastric tissues. In the evaluations, degenerative and necrotic changes and mononuclear cell infiltration areas were observed in the TNBS group, but such changes could be improved with Vit. D and UD applications. The results suggest that the combination of the Vit. D and UD extract may have a protective and therapeutic role in mitigating TNBS-induced damage to the gastric tissues, potentially through the regulation of SSTR, AQP-1, caspase-3, and TNF-a expression. This indicates a promising avenue for further research and the exploration of these compounds in the context of gastrointestinal health.en_US
dc.identifier.doi10.17221/111/2023-VETMED
dc.identifier.endpage93en_US
dc.identifier.issn0375-8427
dc.identifier.issn1805-9392
dc.identifier.issue3en_US
dc.identifier.pmid38623153
dc.identifier.startpage84en_US
dc.identifier.urihttps://doi.org/10.17221/111/2023-VETMED
dc.identifier.urihttps://hdl.handle.net/11468/18687
dc.identifier.volume69en_US
dc.identifier.wosWOS:001194946400003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherCzech Academy Agricultural Sciencesen_US
dc.relation.ispartofVeterinarni Medicina
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAquaporin-1en_US
dc.subjectCrohn's Diseaseen_US
dc.subjectSomatostatinen_US
dc.subjectTnf-Alphaen_US
dc.titleEffect of vitamin D3 and a stinging nettle extract on the gastric tissue of rats administered with trinitrobenzene sulfonic aciden_US
dc.titleEffect of vitamin D3 and a stinging nettle extract on the gastric tissue of rats administered with trinitrobenzene sulfonic acid
dc.typeArticleen_US

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