Investigation of Vitamin D Levels in Men with Suspected Infertility

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dc.contributor.authorAsir, Firat
dc.contributor.authorDuran, Senem cetin
dc.contributor.authorAfsin, Muhammet
dc.contributor.authorDuran, Enis
dc.contributor.authorKorak, Tugcan
dc.contributor.authorSahin, Firat
dc.date.accessioned2024-04-24T17:20:50Z
dc.date.available2024-04-24T17:20:50Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractMale infertility may be caused by an impaired sperm functionality, with insufficient vitamin D levels affecting the quantity and development of motile sperm. Given the influence of vitamin D on vital aspects of male infertility, this study aimed to investigate the correlation between vitamin D levels and male infertility, along with exploring the possible mechanism of action. A total of 306 male participants were included. Semen samples were collected and analyzed for semen parameters with demographic features. Patients were classified into two groups based on vitamin D levels of <20 ng/mL (low) and >= 20 ng/mL (high). The Super-PRED, Swiss TargetPrediction, GeneCards, and DisGeNET databases were utilized to retrieve potential molecular targets associated with both vitamin D and male infertility, while the STRING database was employed for constructing protein-protein interaction (PPI) networks and conducting a functional enrichment analysis. A total of 146 patients (47.71%) showed low vitamin D levels and 160 patients (52.29%) had high vitamin D levels. Vitamin D was not strongly influenced by demographic parameters. Vitamin D demonstrated significant positive correlations with type A and B sperm motility. Conversely, it exhibited significant negative correlations with type C and D sperm motility. Hormones (thyroid-stimulating hormone, follicle-stimulating hormone, prolactin, luteinizing hormone, estradiol) were not significantly associated with vitamin D; however, testosterone was significantly positive correlated with vitamin D. Notably, no significant correlation was found between vitamin D levels and iron, ferritin, hemoglobin, hematocrit, calcium, magnesium, and phosphorus levels. The functional annotations of potential vitamin D targets associated with male infertility primarily indicated involvement in regulating infection, the immune response, forkhead box O (FOXO) and hypoxia-inducible factor 1 (HIF1) signals in male infertility. Adequate vitamin D levels are associated with an improved reproductive health, evidenced by positive correlations with hormone levels and sperm motility. Specifically, the FOXO and HIF-1 signaling pathways may be effective in the potential molecular mechanisms underlying the impact of vitamin D on male infertility and/or in the significant correlations identified.en_US
dc.identifier.doi10.3390/life14020273
dc.identifier.issn2075-1729
dc.identifier.issue2en_US
dc.identifier.pmid38398783
dc.identifier.urihttps://doi.org/10.3390/life14020273
dc.identifier.urihttps://hdl.handle.net/11468/19271
dc.identifier.volume14en_US
dc.identifier.wosWOS:001174828400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofLife-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectVitamin Den_US
dc.subjectSperm Motilityen_US
dc.subjectInfertilityen_US
dc.subjectFunctional Enrichmenten_US
dc.titleInvestigation of Vitamin D Levels in Men with Suspected Infertilityen_US
dc.titleInvestigation of Vitamin D Levels in Men with Suspected Infertility
dc.typeArticleen_US

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