Assessment of thyroid function in children aged 1-13 years with beta-thalassemia major

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dc.authorid0000-0002-2524-2124en_US
dc.authorid0000-0002-5299-9480en_US
dc.authorid0000-0001-8463-2723en_US
dc.contributor.authorPirinççioğlu, Ayfer Gözü
dc.contributor.authorDeniz, Turgay
dc.contributor.authorGökalp, Deniz
dc.contributor.authorBeyazit, Nurcan
dc.contributor.authorHaspolat, Yusuf Kenan
dc.contributor.authorSöker, Murat
dc.date.accessioned2021-12-01T06:31:31Z
dc.date.available2021-12-01T06:31:31Z
dc.date.issued2011en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractObjective: Hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major. This study aimed to evaluate thyroid dysfunctions in patients with beta-thalassemia major and to see if they appear in the earlier period of life. Methods: Thyroid function and iron load status were evaluated in 90 children with a mean age of 7.17±3.78 years with beta-thalassemia major by measuring serum free thyroxin (FT4), serum free triiodothyronine (FT3), total thyroxin (T3), serum total triiodothyronine (T4), thyroid-stimulating hormone (TSH) and ferritin levels from serum of patients admitted to the Pediatric Department, Faculty of Medicine University of Dicle between March 2005 and July 2009. A control group formed from an age-sex matched healthy children with a mean age of 6.98±3.66 years was also included. A standard thyrotropin releasing hormone test was applied to 3 patients who had high TSH levels and were classified as subclinical primer hypothyroidism. The study was designed according to the Declaration of Helsinki and informed consent was obtained from the parents of all participants. Findings: All thyroid parameters in patients were in the normal ranges compared with the controls except three of them which had high TSH levels. Serum ferritin level (2703±1649 ng/mL) in patients was significantly higher than in controls (81.5±15.5 ng/mL). Conclusion: The work implies that hypothyroidism could be even seen in the first decade of life in patients with beta-thalassemia major in spite of improved hematological cares.en_US
dc.identifier.citationPirinççioğlu, A. G., Deniz, T., Gökalp, D., Beyazit, N., Haspolat, Y. K., Söker, M. ve diğerleri. (2011). Assessment of thyroid function in children aged 1-13 years with beta-thalassemia major. Iranian Journal of Pediatrics, 21(1), 77-82.en_US
dc.identifier.endpage82en_US
dc.identifier.issn2008-2150
dc.identifier.issn2008-2142
dc.identifier.issue1en_US
dc.identifier.pmid23056768
dc.identifier.startpage77en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/23056768/
dc.identifier.urihttps://hdl.handle.net/11468/8346
dc.identifier.volume21en_US
dc.identifier.wosWOS:000291290400013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorPirinççioğlu, Ayfer Gözü
dc.institutionauthorDeniz, Turgay
dc.institutionauthorBeyazit, Nurcan
dc.institutionauthorHaspolat, Yusuf Kenan
dc.institutionauthorSöker, Murat
dc.language.isoenen_US
dc.publisherTehran University of Medical Sciencesen_US
dc.relation.ispartofIranian Journal of Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-thalassemiaen_US
dc.subjectChelation therapyen_US
dc.subjectHypothyroidismen_US
dc.subjectIron overloaden_US
dc.subjectSplenectomyen_US
dc.titleAssessment of thyroid function in children aged 1-13 years with beta-thalassemia majoren_US
dc.titleAssessment of thyroid function in children aged 1-13 years with beta-thalassemia major
dc.typeArticleen_US

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