Tissue leptin levels in patients with breast cancer

Basit Öğe Kaydı
dc.contributor.authorKaraduman, M.
dc.contributor.authorBilici, A.
dc.contributor.authorOzet, A.
dc.contributor.authorSengul, A.
dc.contributor.authorMusabak, U.
dc.contributor.authorAlomeroglu, M.
dc.date.accessioned2024-04-24T17:49:48Z
dc.date.available2024-04-24T17:49:48Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: High leptin serum levels, overexpression of leptin and its two main receptor isoforms, OBR-L and OBR-S, have been documented in breast cancer patients. In the present study, the relationship between tissue leptin levels and breast cancer was evaluated. Methods: Thirty-three normal breast tissue samples and 33 breast cancer tissue samples from 33 patients with breast cancer were evaluated. The association of tissue leptin levels and important prognostic factors related to breast cancer was analyzed. Results: Mean tissue leptin levels in breast cancer tissue samples (5.02 +/- 1.06 pg/ml) were significantly higher than those found in normal breast tissue (2.02 +/- 0.83 pg/ml; p=0.01). No correlation was found in tissue leptin levels and menopausal status, hormone receptor and HER-2/neu status, lymph node involvement, and histopathologic features. Conclusion: High leptin levels were significantly higher in breast cancer tissue compared with normal tissue. No special correlation was found between tissue leptin levels and different clinicopathological characteristics.en_US
dc.identifier.endpage372en_US
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue2en_US
dc.identifier.pmid20658737
dc.identifier.startpage369en_US
dc.identifier.urihttps://hdl.handle.net/11468/22965
dc.identifier.volume15en_US
dc.identifier.wosWOS:000279655900026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherImprimatur Publicationsen_US
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Canceren_US
dc.subjectCancer Tissueen_US
dc.subjectLeptinen_US
dc.subjectNormal Breast Tissueen_US
dc.subjectPrognostic Factoren_US
dc.titleTissue leptin levels in patients with breast canceren_US
dc.titleTissue leptin levels in patients with breast cancer
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu