The Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms

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dc.contributor.authorAr, M. Cem
dc.contributor.authorBuyuktas, Deram
dc.contributor.authorEskazan, A. Emre
dc.contributor.authorAydin, Seniz Ongoren
dc.contributor.authorTanrikulu, Eda
dc.contributor.authorBaslar, Zafer
dc.contributor.authorBuyru, A. Nur
dc.date.accessioned2024-04-24T17:27:44Z
dc.date.available2024-04-24T17:27:44Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Bone marrow fibrosis is the second most common complication that causes morbidity and mortality in patients with Philadelphia-negative myeloproliferative neoplasms (MPNs). The aim of this study was to investigate the association between JAK2V617F mutation and bone marrow fibrosis at diagnosis in patients with MPNs. Material and Methods: In total, 149 patients with MPNs were retrospectively evaluated to determine if there was an association between the histological grade of bone marrow fibrosis and JAK2V617F mutation. Results: In all, 67.7% of the patients carried the mutated JAK2 gene. The presence of JAK2V617F mutation was not associated with the occurrence of bone marrow fibrosis (P = 0.55) or its grade at diagnosis (P = 0.65). Conclusion: Molecular mechanisms or genetic defects other than JAK2V617F may underlie the occurrence of bone marrow fibrosis in patients with MPNs.en_US
dc.identifier.doi10.5505/tjh.2012.58751
dc.identifier.endpage247en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue3en_US
dc.identifier.pmid24744667
dc.identifier.startpage242en_US
dc.identifier.urihttps://doi.org/10.5505/tjh.2012.58751
dc.identifier.urihttps://hdl.handle.net/11468/20165
dc.identifier.volume29en_US
dc.identifier.wosWOS:000313935800007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Journal of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectJak2v617fen_US
dc.subjectMyeloproliferative Diseaseen_US
dc.subjectBone Marrow Fibrosisen_US
dc.titleThe Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasmsen_US
dc.titleThe Association Between JAK2V617F Mutation and Bone Marrow Fibrosis at Diagnosis in Patients with Philadelphia-Negative Chronic Myeloproliferative Neoplasms
dc.typeArticleen_US

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