In vitro inhibition of advanced glycation end product formation by ethanol extract of milk thistle (Silybum marianum L.) seed

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dc.contributor.authorInceoren, Nesrin
dc.contributor.authorEmen, Sevil
dc.contributor.authorToptanci, Bircan Ceken
dc.contributor.authorKizil, Goksel
dc.contributor.authorKizil, Murat
dc.date.accessioned2024-04-24T16:18:20Z
dc.date.available2024-04-24T16:18:20Z
dc.date.issued2022
dc.departmentDicle Üniversitesien_US
dc.description.abstractGlycation of proteins by reducing sugars produces toxic and immunogenic compounds called advanced gly-cation end products (AGEs). AGEs plays important role in the progression of typical diabetes complications. Silybum marianum L. contains powerful antioxidants that quench free radicals, which are unstable and reac-tive compounds that damage DNA and cellular structures. This study aimed to evaluate the antioxidant activ-ities and the inhibitory effects of ethanol:water (1:1) extract of the Silybum marianum seed (SlyE) and silymarin (Sly) on fructose mediated protein glycation and AGE formation. The total amount of silymarin in SlyE was found to be 2.59 mg/gDW by HPLC. The composition of phenolic in the extract was found to be 262.70 mg gallic acid (GAE)/mg extract. The composition of flavonoids in the extract was found to be 10.50 mg quercetin (QUE)/mg extract. The seed exhibited ABTS radical cation decolourization inhibition with 70.4% at 300 mg concentration. Ferric reducing power of the extract was also evaluated. The SlyE and Sly also demonstrated strong inhibitory effects on the production AGEs in bovine serum albumin (BSA)/fructose model. SlyE and Sly has a significant effect in preventing oxidative protein damage, including the effect on the formation of fructosamines, a-dicarbonyls and protein carbonyl content (PCC). SlyE and Sly were able to prevent the glycoxidative damage of BSA. It can be concluded that the SlyE has antiglycating potential as well as antioxidant properties. (C) 2022 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDicle University Scientific Research Projects Coordinator [Fen 15008]en_US
dc.description.sponsorshipThis work was supported by grants from the Dicle University Scientific Research Projects Coordinator (D_UBAP-Project No: Fen 15008).en_US
dc.identifier.doi10.1016/j.sajb.2022.06.062
dc.identifier.endpage692en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85133663555
dc.identifier.scopusqualityQ1
dc.identifier.startpage682en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2022.06.062
dc.identifier.urihttps://hdl.handle.net/11468/16010
dc.identifier.volume149en_US
dc.identifier.wosWOS:000829420300002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced Glycation End -Products (Ages)en_US
dc.subjectAntiglycationen_US
dc.subjectProteins Glycationen_US
dc.subjectSilybum Marianum Len_US
dc.titleIn vitro inhibition of advanced glycation end product formation by ethanol extract of milk thistle (Silybum marianum L.) seeden_US
dc.titleIn vitro inhibition of advanced glycation end product formation by ethanol extract of milk thistle (Silybum marianum L.) seed
dc.typeArticleen_US

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