Investigation of antihyperglycemic potentials of seven Centaurea L. species through in vitro studies and characterization of possible bioactive phenolics by LC–MS/MS and molecular docking approach

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dc.authorid0000-0002-4090-7227en_US
dc.authorid0000-0002-8006-2054en_US
dc.authorid0000-0001-9561-8994en_US
dc.contributor.authorKahraman, Çiğdem
dc.contributor.authorAydın, Zekiye Ceren Arıtuluk
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÇakır, Oğuz
dc.contributor.authorÖzenver, Nadire
dc.date.accessioned2025-02-19T11:31:16Z
dc.date.available2025-02-19T11:31:16Z
dc.date.issued2025en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe taxon Centaurea L., a natural wealth with a high endemism rate in Türkiye, has been traditionally used in treating diabetes. This study aimed to determine the diabetes-associated biological activities and phytochemical content of different solvent extracts of Centaurea benedicta (L.) L, C. cariensis Boiss. subsp. microlepis (Boiss.) Wagenitz, C. drabifolia Sm. subsp. cappadocica (DC.) Wagenitz, C. iberica Trev. ex. Sprengel, C. solstitialis L. subsp. solstitialis, C. urvillei DC. subsp. stepposa Wagenitz, and C. virgata Lam. via in vitro and in silico methods. The antihyperglycemic potentials were estimated by determining the extracts’ α-amylase, α-glucosidase, and DPP-4 enzyme inhibitory abilities. The antioxidant capacities along with the total phenolic and flavonoid contents of the plant extracts were estimated by various methods. An LC-MS/MS analysis was used for the quantitative determination of the phytochemical components of the active extracts. In silico docking approach pointed out possible substances accounting for biological activity. Evaluating the α-glucosidase inhibitory activity of the plant extracts, the methanol and ethyl acetate extracts of C. urvillei were identified as the most active plant extracts with the lowest IC50 values on α-glucosidase (17.9 and 17.6 µg/mL, respectively). None of the tested extracts inhibited α-amylase and DPP-4. The most abundant compounds in the active extracts were achieved by the LC-MS/MS method. Among those, cosmosiin and cynaroside were identified as promising antihyperglycemic agents based on molecular docking studies, suggesting their potential accounting for α-glucosidase inhibitory activity. Alcoholic and hydroalcoholic plant extracts generally exerted high antioxidant capacity. To conclude, specifically C. urvillei extracts along with cosmosiin and cynaroside were determined as potential and promising antihyperglycemic agents. The traditional usage of Centaurea species was verified, leading to the design of forthcoming projects associated with the antihyperglycemic potential of Centaurea species.en_US
dc.description.sponsorshipHacettepe University THD-2021-19413en_US
dc.identifier.citationKahraman, Ç., Aydın, Z. C. A., Yılmaz, M. A., Çakır, O. ve Özenver, N. (2025). Investigation of antihyperglycemic potentials of seven Centaurea L. species through in vitro studies and characterization of possible bioactive phenolics by LC–MS/MS and molecular docking approach. South African Journal of Botany, 176, 248-260.en_US
dc.identifier.endpage260en_US
dc.identifier.issn0254-6299
dc.identifier.scopus2-s2.0-85210285404
dc.identifier.scopusqualityQ1
dc.identifier.startpage248en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0254629924007142?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/29471
dc.identifier.volume176en_US
dc.identifier.wosWOS:001370783300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorÇakır, Oğuz
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.isversionof10.1016/j.sajb.2024.11.004en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidant capacityen_US
dc.subjectCentaureaen_US
dc.subjectDPP-4en_US
dc.subjectLC–MS/MSen_US
dc.subjectMolecular dockingen_US
dc.subjectα-amylaseen_US
dc.subjectα-glucosidaseen_US
dc.titleInvestigation of antihyperglycemic potentials of seven Centaurea L. species through in vitro studies and characterization of possible bioactive phenolics by LC–MS/MS and molecular docking approachen_US
dc.titleInvestigation of antihyperglycemic potentials of seven Centaurea L. species through in vitro studies and characterization of possible bioactive phenolics by LC–MS/MS and molecular docking approach
dc.typeArticleen_US

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