Microangiopathic hemolytic anemia, thrombocytopenia and acute renal failure associated with acute brucellosis
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Tarih
2001
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Microangiopathic hemolytic anemia and severe thrombocytopenia are rare in childhood brucellosis: there are few reported cases. We report our experience with a 9-year-old boy with brucella infection presenting at the onset as a microangiopathic hemolytic anemia, severe thrombocytopenia and acute renal failure with coexisting gastrointestinal bleeding and gross hematuria. Peripheral blood smear examination showed hemolytic anemia, thrombocytopenia, and leukopenia. Bone marrow aspiration specimen revealed hypercellularity, histiocytic proliferation, and hemophagocytosis of the typical features associated with Brucella infection. Results of agglutination tests for Brucella in CSF and serum were positive. The patient recovered completely after appropriate antimicrobial therapy (consisting of rifampin, doxycycline, gentamicin) and fresh-frozen plasma, platelet transfusion, and rehydration therapy. We suggest that brucellosis must be investigated when hemolytic uremic syndrome (HUS) like disease exists with no known etiology, especially in endemic countries.
Açıklama
Anahtar Kelimeler
Microangiopathic Hemolytic Anemia, Renal Failure, S. Brucellosis, Thrombocytopenia
Kaynak
International Pediatrics
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
16
Sayı
2
