Phytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts

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dc.contributor.authorBoga, M.
dc.contributor.authorErtas, A.
dc.contributor.authorEroglu-Ozkan, E.
dc.contributor.authorKizil, M.
dc.contributor.authorCeken, B.
dc.contributor.authorTopcu, G.
dc.date.accessioned2024-04-24T16:18:20Z
dc.date.available2024-04-24T16:18:20Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis is the first study on phytochemical analysis and biological evaluation of Hypericum capitatum Choisy var. capitatum (HCC) endemic to Turkey with exception of essential oil analysis. Hyperoside and isoquercetin (25.7 +/- 0.02 and 17.8 +/- 0.02 mu g/mg extract, respectively) were determined as the main compounds of the methanol extract. The major compounds of essential oil of HCC were found to be spathulenol and iso-longifolene (12.9% and 11.2%, respectively), and linoleic and palmitic acids (26.8% and 18.3%, respectively) were the main fatty acids. The methanol extract whose antioxidant activities studied for the first time was found to have moderate activity in beta-carotene bleaching method (IC50: 41.69 +/- 1.29 mu g/mL) and was found to be the most active extract in scavenging of DPPH free radical (IC50: 16.82 +/- 0.58 mu g/mL) and ABTS cation radical (IC50: 9.24 +/- 0.28 mu g/mL) and CUPRAC assays. Among the prepared four extracts of HCC, the methanol extract showed highest activity against Escherichia coli with an MIC value of 10 mu g/mL, and the methanol extract was also found to have high DNA damage protective activity. The methanol extract exhibited high butyrylcholinesterase inhibitory activity (70.74%). Thus, H. capitatum var. capitatum can be regarded as a potential natural antioxidant, antimicrobial, anticholinesterase source and DNA damage inhibitor. (C) 2016 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.sajb.2016.02.204
dc.identifier.endpage257en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-84963828985
dc.identifier.scopusqualityQ1
dc.identifier.startpage249en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2016.02.204
dc.identifier.urihttps://hdl.handle.net/11468/16004
dc.identifier.volume104en_US
dc.identifier.wosWOS:000375936200030
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofSouth African Journal of Botany
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHypericum Capitatum Var. Capitatumen_US
dc.subjectHplcen_US
dc.subjectGc-Msen_US
dc.subjectAntioxidanten_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntimicrobialen_US
dc.subjectDna Damage Protectionen_US
dc.titlePhytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extractsen_US
dc.titlePhytochemical analysis, antioxidant, antimicrobial, anticholinesterase and DNA protective effects of Hypericum capitatum var. capitatum extracts
dc.typeArticleen_US

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