Can aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?

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dc.contributor.authorAlabalik, Ulas
dc.contributor.authorTurkcu, Gul
dc.contributor.authorKeles, Ayse Nur
dc.contributor.authorIbiloglu, Ibrahim
dc.contributor.authorOzler, Ali
dc.contributor.authorUrakci, Zuhat
dc.contributor.authorBuyukbayram, Huseyin
dc.date.accessioned2024-04-24T17:07:45Z
dc.date.available2024-04-24T17:07:45Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractGenerally, uterine leiomyosarcoma is easily diagnosed. However, uterine smooth muscle tumours which show atypical histological features and unusual growth patterns may mimic malignancy and may not be easily diagnosed. In this study, our aim is to show the expressions of Aquaporin3, Aquaporin7 and Aquaporin9 in uterine smooth muscle tumours, and to investigate if aquaglyceroporins can be used as diagnostic and prognostic markers to start rapidly an appropriate treatment for patients with these tumours in order to extend the survival time. We determined that there had been 74 patients diagnosed with uterine smooth muscle tumours. We divided patients into four groups based on the diagnosis: bizarre leiomyoma, smooth muscle tumour of uncertain malignant potential, leiomyosarcoma and leiomyoma. Aquaporin3, Aquaporin7 and Aquaporin9 were detected by using monoclonal anti-Aquaporin3, anti-Aquaporin7 and anti-Aquaporin9 antibodies, respectively. In leiomyosarcoma group, we observed a statistically significant relation of Aquaporin3 expression with survival time, grade, stage, mitotic index and Ki-67 score. A significant relation of both Aquaporin7 and Aquaporin9 expressions with survival time, grade, stage was not statistically detected in leiomyosarcoma group. The decrease of Aquaporin3 expression can be used as important diagnostic and prognostic marker. Aquaporin7 and Aquaporin9 expressions cannot be used as diagnostic and prognostic markers.en_US
dc.identifier.doi10.1080/13102818.2016.1240018
dc.identifier.endpage155en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84990927259
dc.identifier.scopusqualityQ3
dc.identifier.startpage148en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2016.1240018
dc.identifier.urihttps://hdl.handle.net/11468/16956
dc.identifier.volume31en_US
dc.identifier.wosWOS:000390379500021
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAquaglyceroporinen_US
dc.subjectAquaporinen_US
dc.subjectLeiomyosarcomaen_US
dc.subjectSmooth Muscle Tumour Of Uncertain Malignant Potentialen_US
dc.titleCan aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?en_US
dc.titleCan aquaporins be used as diagnostic and prognostic markers for uterine smooth muscle tumours?
dc.typeArticleen_US

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