Liver Histology of Patients with Hepatitis C Virus Infection and Normal Alanine Aminotransferase Levels

Basit Öğe Kaydı
dc.contributor.authorAygen, Bilgehan
dc.contributor.authorDeniz, Kemal
dc.contributor.authorAkhan, Sila
dc.contributor.authorCelen, Mustafa Kemal
dc.contributor.authorYildiz, Orhan
dc.contributor.authorAyaz, Celal
dc.contributor.authorDogan, Suat Ali
dc.date.accessioned2024-04-24T17:27:29Z
dc.date.available2024-04-24T17:27:29Z
dc.date.issued2012
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: In this study, our objective is to evaluate histological changes in livers of hepatitis C virus (HCV)-infected patients with normal alanine aminotransferase (ALT) levels. Methods: 72 patients over 16 years old, with chronic hepatitis C (CHC) and normal ALT levels were evaluated in this multicenter retrospective study. Persistently normal ALT level was defined as 2 or 3 normal ALT levels at intervals of at least 1 month during 6 months. Demographic data, year of diagnosis, at least 2 ALT values within 6 months, hepatitis markers, results of HCV RNA and the liver biopsy were all evaluated. Serological markers have been tested with different kits. HCV RNA has been studied by RT-PCR with dynamic range and sensitivity of different kits. All biopsies were evaluated again by the same pathologist. Results: The mean age was 44 +/- 13 years and 61.1% were female. HCV RNA levels were between 1.53x10(2)-1.13x10(8) IU/ml. The mean ALT levels were 30.3 +/- 9.6 IU/lt. The mean grade of necro-inflammation was 4.67 +/- 1.96 and mean staging of fibrosis was 1.03 +/- 1.13. The ratios of minimal, mild and moderate activity in the liver biopsies were 48.6%, 45.3% and, 2.8%, respectively. Rate of portal-periportal fibrosis, bridging fibrosis and incomplete cirrhosis were 51.4%, 6.9%, and 1.4%, respectively. Conclusions: ALT level is a poor indicator of liver disease activity in patients with CHC. Patients with indication for treatment should be evaluated for liver biopsy.en_US
dc.identifier.doi10.5152/kd.2012.06
dc.identifier.endpage23en_US
dc.identifier.issn1301-143X
dc.identifier.issn1309-1484
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84866390881
dc.identifier.scopusqualityQ4
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.5152/kd.2012.06
dc.identifier.urihttps://hdl.handle.net/11468/19984
dc.identifier.volume25en_US
dc.identifier.wosWOS:000420928300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherAvesen_US
dc.relation.ispartofKlimik Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatitis C Virusen_US
dc.subjectAlanine Transaminaseen_US
dc.subjectHistologyen_US
dc.subjectChronic Liver Diseaseen_US
dc.titleLiver Histology of Patients with Hepatitis C Virus Infection and Normal Alanine Aminotransferase Levelsen_US
dc.titleLiver Histology of Patients with Hepatitis C Virus Infection and Normal Alanine Aminotransferase Levels
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu