Investigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabetics

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dc.authorid0000-0003-1756-9757en_US
dc.authorid0000-0003-0108-4149en_US
dc.contributor.authorİpek, Polat
dc.contributor.authorTaşdemir, Ezel
dc.contributor.authorKoçyiğit, Yüksel
dc.date.accessioned2023-04-07T10:37:27Z
dc.date.available2023-04-07T10:37:27Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractIntroduction: The current antidiabetic drugs have adverse side effects and the effects may decrease overtime depending oncontinuous use. In recent years, phytochemicals of natural plant origin, which show antidiabetic properties and have fewerside effects, have been the subject of research. However, studies and clinical studies on the antidiabetic and hypoglycemiceffects of Potentilla fulgens are still not enough. We aimed to examine the antidiabetic effects of P. fulgens in diabetic ratsand to contribute to new treatment approaches by comparing them with other antidiabetics.Methods: In this study, rats were divided into seven groups, one control and six diabetic groups as seven rats in each group.The rats in which diabetes was induced by streptozotocin were sacrificed after treatment with two different doses of intraperitonealand intragastric P. fulgens and standard antidiabetic drugs, metformin and gliclazide for 3 weeks.Results: Intraperitoneal administration of P. fulgens significantly improved the activity of liver enzymes related to fastingblood glucose levels and carbohydrate metabolism. Intragastric 450 mg/kg/day P. fulgens did not show adequate antidiabeticeffects. However, P. fulgens administered twice the usual dose (900 mg/kg/day) caused significant antidiabetic effects.Compared with metformin and gliclazide, it was found that P. fulgens had similar effects at high doses.Discussion and Conclusion: According to our findings, P. fulgens improves the activity of liver enzymes related to bloodglucose and glucose metabolism in diabetic rats and has significant antidiabetic effects.en_US
dc.identifier.citationİpek, P., Taşdemir, E. ve Koçyiğit, Y. (2019). Investigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabetics. Haydarpaşa Numune Medical Journal, 59(1), 1-7.en_US
dc.identifier.doi10.14744/hnhj.2018.93898
dc.identifier.endpage7en_US
dc.identifier.issn2630-5720
dc.identifier.issn2687-346X
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.trdizinidTRDizinIdYok
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/326248
dc.identifier.urihttps://hdl.handle.net/11468/11640
dc.identifier.volume59en_US
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKoçyiğit, Yüksel
dc.language.isoenen_US
dc.publisherHaydarpaşa Numune Eğitim ve Araştırma Hastanesien_US
dc.relation.ispartofHaydarpaşa Numune Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectGliclazideen_US
dc.subjectMetforminen_US
dc.subjectPotentilla fulgensen_US
dc.titleInvestigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabeticsen_US
dc.titleInvestigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabetics
dc.typeArticleen_US

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