Investigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabetics
Yükleniyor...
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Haydarpaşa Numune Eğitim ve Araştırma Hastanesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: The current antidiabetic drugs have adverse side effects and the effects may decrease overtime depending oncontinuous use. In recent years, phytochemicals of natural plant origin, which show antidiabetic properties and have fewerside effects, have been the subject of research. However, studies and clinical studies on the antidiabetic and hypoglycemiceffects of Potentilla fulgens are still not enough. We aimed to examine the antidiabetic effects of P. fulgens in diabetic ratsand to contribute to new treatment approaches by comparing them with other antidiabetics.Methods: In this study, rats were divided into seven groups, one control and six diabetic groups as seven rats in each group.The rats in which diabetes was induced by streptozotocin were sacrificed after treatment with two different doses of intraperitonealand intragastric P. fulgens and standard antidiabetic drugs, metformin and gliclazide for 3 weeks.Results: Intraperitoneal administration of P. fulgens significantly improved the activity of liver enzymes related to fastingblood glucose levels and carbohydrate metabolism. Intragastric 450 mg/kg/day P. fulgens did not show adequate antidiabeticeffects. However, P. fulgens administered twice the usual dose (900 mg/kg/day) caused significant antidiabetic effects.Compared with metformin and gliclazide, it was found that P. fulgens had similar effects at high doses.Discussion and Conclusion: According to our findings, P. fulgens improves the activity of liver enzymes related to bloodglucose and glucose metabolism in diabetic rats and has significant antidiabetic effects.
Açıklama
Anahtar Kelimeler
Diabetes mellitus, Gliclazide, Metformin, Potentilla fulgens
Kaynak
Haydarpaşa Numune Medical Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
59
Sayı
1
Künye
İpek, P., Taşdemir, E. ve Koçyiğit, Y. (2019). Investigation of possible antidiabetic effects of potentilla fulgens in diabetic rats and comparison with other antidiabetics. Haydarpaşa Numune Medical Journal, 59(1), 1-7.
