Comparison of the treatment efficacy of continuous renal replacement therapy and intermittent hemodialysis in patients with acute kidney injury admitted to the intensive care unit

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dc.authorid0000-0002-8101-2497en_US
dc.authorid0000-0001-7657-3065en_US
dc.authorid0000-0002-7768-2455en_US
dc.contributor.authorAydın, Fatma Yılmaz
dc.contributor.authorAydın, Emre
dc.contributor.authorKadiroğlu, Ali Kemal
dc.date.accessioned2022-03-21T11:57:54Z
dc.date.available2022-03-21T11:57:54Z
dc.date.issued2022en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıklar Ana Bilim Dalıen_US
dc.descriptionWOS:000758928100011
dc.descriptionPMID: 35242474
dc.description.abstractAbstract Introduction and aim Acute kidney injury (AKI) is part of the multiple organ dysfunction syndrome in critically ill patients and is a common condition in intensive care units (ICUs). Renal replacement therapy (RRT) is the cornerstone of treatment for AKI in critically ill patients. This patient population has a high mortality rate despite RRT. There are two methods of RRT for patients in ICUs: intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT). Both CRRT and IHD similarly provide adequate metabolic control. We aimed to compare these two RRT modalities in terms of ICU stay, mortality, and laboratory recovery in these patients with high mortality. Materials and methods A total of 120 patients with AKI who needed RRT in the ICU were included in the study (CRRT, n:40; IHD, n:80). Acute Physiology and Chronic Health Evaluation (APACHE) II, Sepsis-related Organ Failure Assessment (SOFA), and Simplified Acute Physiology Score (SAPS)-II scores at the time of admission to the ICU were calculated. Mean arterial pressure, urea, creatinine, sodium, potassium, calcium, pH, lactate, and bicarbonate levels were measured before and after dialysis. Patients were classified as living and deceased. Factors affecting the length of stay in the intensive care unit and 30-day mortality were evaluated. The variability in laboratory parameters between groups before and after dialysis was examined. The groups were compared with these parameters. Results Sixty-one point seven percent (61.7%, n:74) of the patients were female. The mean age was 62.90 +/- 13.64 years. At the time of admission to the ICU, the patients' SAPS II score was 45.05 +/- 12.76, APACHE II score was 22.05 +/- 6.32, and SOFA score was 8.26 +/- 2.48. 66.7% (n:80) of the patients included in the study died, and the length of stay of these patients in the ICU was 12.85 +/- 10.23 days. When the groups were compared, SAPS II, APACHE II scores, and SOFA scores were significantly higher in the CRRT group than in the IHD group (p:0.038, p:0.015, p:0.027, respectively). Although the length of stay in the ICU was shorter in the CRRT group, it was not statistically significant (p:0.075). There was no statistically significant difference between the groups in terms of mortality (p: 0.891). SAPS-II, APACHE II, and SOFA score affected 30-day mortality while age, gender, and RRT modalities were not associated with mortality. The improvement in laboratory parameters between the pre and post-RRT groups was statistically more significant in the IHD group (p<0.001). It was determined that there was a statistically greater decrease in mean arterial pressure in the IHD group (p<0.001). Conclusions It was determined that there was no difference between the CRRT and IHD modalities applied in patients with AKI admitted to the ICU in terms of mortality and length of stay in the ICU. It was observed that both modalities improved on laboratory parameters, but the improvement was greater in the IHD group. However, it was determined that there was a statistically greater decrease in mean arterial pressure in the IHD group.en_US
dc.identifier.citationAydin, F. Y., Aydin, E. ve Kadiroğlu, A.K. (2022). Comparison of the treatment efficacy of continuous renal replacement therapy and intermittent hemodialysis in patients with acute kidney injury admitted to the intensive care unit. Cureus Journal of Medical Science, 14(1)en_US
dc.identifier.doi10.7759/cureus.21707
dc.identifier.issn2168-8184
dc.identifier.issue1en_US
dc.identifier.pmid35242474
dc.identifier.urihttps://www.cureus.com/articles/84793-comparison-of-the-treatment-efficacy-of-continuous-renal-replacement-therapy-and-intermittent-hemodialysis-in-patients-with-acute-kidney-injury-admitted-to-the-intensive-care-unit
dc.identifier.urihttps://hdl.handle.net/11468/9465
dc.identifier.volume14en_US
dc.identifier.wosWOS:000758928100011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorAydın, Fatma Yılmaz
dc.institutionauthorAydın, Emre
dc.institutionauthorKadiroğlu, Ali Kemal
dc.language.isoenen_US
dc.publisherCureus Inc.en_US
dc.relation.ispartofCureus Journal of Medical Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMortalityen_US
dc.subjectIntensive care uniten_US
dc.subjectIntermittent hemodialysisen_US
dc.subjectContinuous renal replacement therapy (crrt)en_US
dc.subjectRenal replacement therapy (rrt)en_US
dc.subjectAcute kidney injuryen_US
dc.titleComparison of the treatment efficacy of continuous renal replacement therapy and intermittent hemodialysis in patients with acute kidney injury admitted to the intensive care uniten_US
dc.titleComparison of the treatment efficacy of continuous renal replacement therapy and intermittent hemodialysis in patients with acute kidney injury admitted to the intensive care unit
dc.typeArticleen_US

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