Novel Terpenoids with Potential Anti-Alzheimer Activity from Nepeta obtusicrena

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dc.contributor.authorYilmaz, Anil
dc.contributor.authorBoga, Mehmet
dc.contributor.authorTopcu, Gulacti
dc.date.accessioned2024-04-24T17:37:42Z
dc.date.available2024-04-24T17:37:42Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractDichloromethane extract of Nepeta obtusicrena Boiss. Et Kotschy Ex Hedge afforded two novel terpenoids, a diterpenoid and a triterpenoid in addition to two known triterpenoids, oleanolic acid and ursolic acid. Purification of the diterpenoid was carried out by HPLC, and its structure was elucidated as 14a-acetoxy-6-oxo-abieta-7-ene, and structure of the triterpenoid was elucidated as 2 alpha, 3 beta, 19 alpha, 24-tetrahydroxy-11-oxo-olean-12-ene. Both of the novel terpenes were obtained from nature for the first time and named as obtusicrenone and nemrutolone, respectively. Anticholinesterase (anti-Alzheimer) and antioxidant activities [DPPH free radical scavenging activity, ABTS cation radical scavenging activity, lipid peroxidation inhibitory activity, CUPRAC (Cupric Reducing Antioxidant Capacity)] of the dichloromethane and methanol extracts and the isolated four terpenoids were investigated. Both of the extracts and the isolated four terpenoids exhibited high anticholinesterase activity, particularly against acetylcholinesterase (AChE) enzyme. None of the samples tested showed high antioxidant activity.en_US
dc.description.sponsorshipIstanbul Technical University, Department of Scientific Research Projects [34028]en_US
dc.description.sponsorshipThe authors, A. Yilmaz and G. Topcu would like to thank Istanbul Technical University, Department of Scientific Research Projects for financial support for this study as a part of master thesis of Anil Yilmaz (Project No: 34028). They also thank Dr. Tuncay Dirmenci for the collection and identification of the plant, and Pinar Caglar for the help during HPLC work.en_US
dc.identifier.endpage541en_US
dc.identifier.issn1307-6167
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84959457722
dc.identifier.scopusqualityQ2
dc.identifier.startpage530en_US
dc.identifier.urihttps://hdl.handle.net/11468/21128
dc.identifier.volume10en_US
dc.identifier.wosWOS:000372804700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherAcg Publicationsen_US
dc.relation.ispartofRecords of Natural Products
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNepeta Obtusicrenaen_US
dc.subjectAbietane Diterpenoiden_US
dc.subjectTriterpenoidsen_US
dc.subjectAnticholinesterase Activityen_US
dc.subjectAntioxidant Activityen_US
dc.titleNovel Terpenoids with Potential Anti-Alzheimer Activity from Nepeta obtusicrenaen_US
dc.titleNovel Terpenoids with Potential Anti-Alzheimer Activity from Nepeta obtusicrena
dc.typeArticleen_US

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