Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand

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dc.authorid0000-0003-0401-7419en_US
dc.authorid0000-0001-7055-8139en_US
dc.authorid0000-0003-0419-7798en_US
dc.authorid0000-0002-7840-5919en_US
dc.authorid0000-0002-1260-9425en_US
dc.authorid0000-0003-4163-9962en_US
dc.contributor.authorÇakmak, Reşit
dc.contributor.authorAy, Burak
dc.contributor.authorÇınar, Ercan
dc.contributor.authorBaşaran, Eyüp
dc.contributor.authorAkkoç, Senem
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorTaş, Eşref
dc.date.accessioned2023-08-17T12:40:32Z
dc.date.available2023-08-17T12:40:32Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractMetal-based drugs have gained significant importance in medicine in recent years. In this research, a series of new Co(II), Ni (II), Cu (II), Zn(II), and Ru(III) complexes of a Schiff base ligand, (1,5-dimethyl-4-((1-(3-nitrophenyl)ethylidene) amino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one), were prepared for the first time in excellent yields, and characterized by elemental analysis, FT-IR, 1 H NMR, 13C NMR, ICP-OES, and thermal analysis. The in vitro antiproliferative, anticholinesterase, and antioxidant properties of complexes 1–5 were evaluated. The cytotoxic effects of complexes 1–5 on the viability of colon cancer (DLD-1), breast cancer (MDA-MB-231), and healthy lung (Wl-38) cell lines were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method in vitro. The anticancer activities of the ligand and its metal complexes were lower than those of the reference drug, cisplatin. In anticholinesterase activity studies, complex 4 (88.46±0.45% inhibition) in butyrylcholinesterase (BChE) assay showed a higher inhibitory effect than the standard compound galanthamine with 78.14±0.55% inhibition. In antioxidant assays, some complexes showed higher antioxidant activities than standard antioxidant butylated hydroxytoluene (BHT). Among the prepared complexes, complex (4) (IC50=5.91±0.17 µM) in ABTS assay showed the highest antioxidant activity compared to BHT (IC50=16.19 ±0.17 µM). Also, this complex (IC50=10.17±0.36 µM) showed the best antioxidant activity in CUPRAC assay compared to BHT (IC50=39.37±0.12 µM).en_US
dc.identifier.citationÇakmak, R., Ay, B., Çınar, E., Başaran, E., Akkoç, S., Boğa, M. ve diğerleri. (2023). Synthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand. Journal of Molecular Structure, (1292), 1-7.en_US
dc.identifier.doi10.1016/j.molstruc.2023.136225
dc.identifier.endpage7en_US
dc.identifier.issn0022-2860
dc.identifier.issue1292en_US
dc.identifier.scopus2-s2.0-85165317491
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0022286023013169?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/12501
dc.identifier.wosWOS:001149564400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.language.isoenen_US
dc.publisherElsevier B.V.en_US
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetal complexen_US
dc.subjectAnticancer agenten_US
dc.subjectEnzyme inhibitory activityen_US
dc.subjectAntioxidant activityen_US
dc.titleSynthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base liganden_US
dc.titleSynthesis, spectroscopic, thermal analysis and in vitro cytotoxicity, anticholinesterase and antioxidant activities of new Co(II), Ni(II), Cu(II), Zn(II), and Ru(III) complexes of pyrazolone-based Schiff base ligand
dc.typeArticleen_US

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