The effect of chloroquine treatment in malignant astrocytomas on prognosis

Basit Öğe Kaydı
dc.contributor.authorBulut, Turgay
dc.contributor.authorEkici, Mehmet Ali
dc.contributor.authorTucer, Bulent
dc.contributor.authorBasarslan, Seyit Kaan
dc.contributor.authorKamasak, Kagan
dc.contributor.authorKurtsoy, Ali
dc.date.accessioned2024-04-24T17:21:08Z
dc.date.available2024-04-24T17:21:08Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: To investigate the adjuvant role of the antimutagenic agent chloroquine in the treatment of patients with malignant astrocytomas (MAs). Materials and methods: Clinical research was conducted at the Neurosurgery Clinic of the Erciyes University School of Medicine, from September 2003 to April 2007, on 37 patients diagnosed with MA after tumor resection subsequent to craniotomy. Chloroquine treatment was started on a daily dose of 150 mg, additional to the patients' radiotherapy and chemotherapy protocol, and was continued throughout the 43-month surveillance period. A control group was formed of 81 patients with MA after the craniotomy. Results: While the mean survival time of the patients who were treated with chloroquine was found to be 15 months, during the observation period 7 of these patients (18.9%) were alive throughout. In the control group, 20 patients (35.1%) were alive throughout the observation period and their mean survival time was 17 months. There were no statistical differences between the control and chloroquine groups (P > 0.05). Conclusion: The chloroquine treatment was not been found to be effective for the medical treatment of MAs.en_US
dc.identifier.doi10.3906/sag-1203-100
dc.identifier.endpage789en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.startpage782en_US
dc.identifier.trdizinid211702
dc.identifier.urihttps://doi.org/10.3906/sag-1203-100
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/211702
dc.identifier.urihttps://hdl.handle.net/11468/19379
dc.identifier.volume43en_US
dc.identifier.wosWOS:000323610400018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChloroquine Treatmenten_US
dc.subjectMalignant Astrocytomasen_US
dc.subjectPrognosisen_US
dc.subjectAntimutagenic Effecten_US
dc.titleThe effect of chloroquine treatment in malignant astrocytomas on prognosisen_US
dc.titleThe effect of chloroquine treatment in malignant astrocytomas on prognosis
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu