Tissue levels of adiponectin in breast cancer patients

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dc.contributor.authorKaraduman, Mehmet
dc.contributor.authorBilici, Ahmet
dc.contributor.authorOzet, Ahmet
dc.contributor.authorSengul, Ali
dc.contributor.authorMusabak, Ugur
dc.contributor.authorAlomeroglu, Melih
dc.date.accessioned2024-04-24T16:02:40Z
dc.date.available2024-04-24T16:02:40Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground Adiponectin is a new adipocyte- secreted protein and associated with insulin-resistant status, such as type 2 diabetes mellitus and obesity. The inverse correlation between serum adiponectin levels and breast cancer risk was recently documented. On the other hand, the association of tissue adiponectin levels with breast cancer has not been previously reported. Thus, in the present study, the relationship between tissue adiponectin levels and breast cancer was evaluated. Methods We analyzed the correlation between tissue adiponectin levels and the occurrence of breast cancer in a case-control study comprising 27 women with diagnosed and histologically confirmed breast cancer and 33 women with fibroadenoma. In addition, the association of tissue adiponectin levels with the various classical risk factors, such as body mass index, menopausal status and, tumor size, stage, lymph node status, hormonal status were also studied. Results Tissue adiponectin levels in patients with breast cancer (0.75 +/- 0.06) were significantly higher than those in controls (0.68 +/- 0.1) (P = 0.02). The high tissue adiponectin levels were associated with significantly (P = 0.001) an increased risk for breast cancer compared with those in the low tissue adiponectin levels (OR, 1.34; 95% Cl, 1.12-1.84) in breast cancer patients. In addition, postmenopausal women with the high tissue adiponectin levels showed a significantly (P = 0.003) an increased risk for breast cancer compared with women in low tissue adiponectin levels (OR, 1.63; 95% Cl, 1.23-1.90). The correlation between BMI and breast cancer was not found (P > 0.05). Furthermore, the status of estrogen receptor, progesteron receptor, HER-2/neu receptor and lymph nodes involvement were established, no effect on the tissue adiponectin levels in patients with breast cancer and no correlations were detected among tumor stage; tumor size and the levels of tissue adiponectin (P > 0.05). Conclusion Our results suggest that the high tissue adiponectin levels significantly detected in breast cancer patients and associated with an increased risk for breast cancer.en_US
dc.identifier.doi10.1007/s12032-007-0021-0
dc.identifier.endpage366en_US
dc.identifier.issn1357-0560
dc.identifier.issue4en_US
dc.identifier.pmid17917082
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1007/s12032-007-0021-0
dc.identifier.urihttps://hdl.handle.net/11468/14872
dc.identifier.volume24en_US
dc.identifier.wosWOS:000250069000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherHumana Press Incen_US
dc.relation.ispartofMedical Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectinen_US
dc.subjectBreast Canceren_US
dc.subjectBreast Tissueen_US
dc.titleTissue levels of adiponectin in breast cancer patientsen_US
dc.titleTissue levels of adiponectin in breast cancer patients
dc.typeArticleen_US

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