Factors influencing disease recurrence and graft survival in patients who developed end-stage renal disease due to focal segmental glomerulosclerosis and underwent renal transplantation

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dc.authorid0000-0002-6133-3189en_US
dc.contributor.authorYılmaz, Vural Taner
dc.contributor.authorKoçak, Hüseyin
dc.contributor.authorÇetinkaya, Ramazan
dc.contributor.authorÜlger, Burak Veli
dc.contributor.authorSüleymanlar, Gültekin
dc.date.accessioned2021-11-12T12:12:47Z
dc.date.available2021-11-12T12:12:47Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.descriptionWOS:000708153500064
dc.description.abstractAbstract Aim: The aim of our study was to determine the factors effecting disease recurrence and graft survival in patients who developed end-stage renal disease (ESRD) due to focal segmental glomerulosclerosis (FSGS) and underwent renal transplantation (Rtx). Methods: A total of 37 patients with FSGS (female/male: 10/27) who underwent Rtx in our transplant center between 2001 and 2014 were included in the study. The patients were diagnosed with FSGS by biopsy. Comparative analyses were performed in order to determine the factors effecting disease recurrence and graft survival. Plasmapheresis was performed with 40 mL/kg plasma. The diagnosis of the recurrence of FSGS and the acute rejections were also confirmed by biopsy. Results: Statistical analyses revealed that, recurrence rates were higher in Rtx recipients from deceased donor [deceased donor versus living donor, 2 (50.0%) versus 3 (9.1%), P = 0.024]. However, no correlation was found between recurrence and renal replacement treatment (RRT) methods, duration of RRT, preoperative or postoperative prophylactic plasmapheresis, the presence of preoperative nephrotic proteinuria, donor's or recipient's age or gender, kinship with donor, time interval between development of FSGS and ESRD, or performing native nephrectomy. Graft survival rates were higher in Rtx patients that were transplanted from living donor, first-degree relatives, and in patients without recurrence. Conclusion: In countries where organ donation is insufficient, living donors can be used with a low risk of recurrence for Rtx candidates with FSGS. Also, grafts from living donors, particularly from first-degree relatives, have higher survival rates.en_US
dc.identifier.citationYılmaz, V.T., Koçak, H., Çetinkaya, R., Ülger, B.V. ve Süleymanlar, G. (2021). Factors influencing disease recurrence and graft survival in patients who developed end-stage renal disease due to focal segmental glomerulosclerosis and underwent renal transplantation. International Surgery, 105(1-3), 366-373.en_US
dc.identifier.doi10.9738/INTSURG-D-15-00154.1
dc.identifier.endpage373en_US
dc.identifier.issn0020-8868
dc.identifier.issue1-3en_US
dc.identifier.scopus2-s2.0-85117845180
dc.identifier.scopusqualityQ4
dc.identifier.startpage366en_US
dc.identifier.urihttps://meridian.allenpress.com/international-surgery/article/105/1-3/366/11636/Factors-Influencing-Disease-Recurrence-and-Graft
dc.identifier.urihttps://hdl.handle.net/11468/8241
dc.identifier.volume105en_US
dc.identifier.wosWOS:000708153500064
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÜlger, Burak Veli
dc.language.isoenen_US
dc.publisherInt College of Surgeonsen_US
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRenal transplantationen_US
dc.subjectFocal segmental glomerulosclerosisen_US
dc.subjectPlasmapheresisen_US
dc.subjectRecurrenceen_US
dc.subjectPretransplantationen_US
dc.titleFactors influencing disease recurrence and graft survival in patients who developed end-stage renal disease due to focal segmental glomerulosclerosis and underwent renal transplantationen_US
dc.titleFactors influencing disease recurrence and graft survival in patients who developed end-stage renal disease due to focal segmental glomerulosclerosis and underwent renal transplantation
dc.typeArticleen_US

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