Enantioselective transfer hydrogenation of various ketones with novel efficient iridium(III) ferrocenyl-phosphinite catalysts

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dc.contributor.authorMeric, Nermin
dc.contributor.authorAydemir, Murat
dc.date.accessioned2024-04-24T16:15:15Z
dc.date.available2024-04-24T16:15:15Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe asymmetric reduction of prochiral ketones is a pivotal reaction for the preparation of chiral alcohols which form an extremely important class of intermediates for fine chemicals and pharmaceuticals. Especially, iridium-based asymmetric reduction of ketones to enantiomerically enriched alcohols has recently attracted important attention by a number of research groups and interest in this area is growing. Therefore, a series of novel neutral mononuclear iridium(III) ferrocenyl-phosphinite complexes have been prepared and applied in the iridium(III)-catalyzed asymmetric transfer hydrogenation (ATH) of ketones to give corresponding secondary alcohols with outstanding enantioselectivities and reactivities using 2-propanol as the hydrogen source (up to 99% ee and 99% conversion). It was seen that the substituents on the backbone of the ligands resulted in a significant effect on both the activity and % enantioselectivity. Furthermore, the structural elucidation of the complexes was carried out by elemental analysis, IR and multi-nuclear NMR spectroscopic data. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipDicle University [FEN.15.021, FEN.15.022]en_US
dc.description.sponsorshipPartial support from Dicle University (Project number: FEN.15.021 and FEN.15.022) is gratefully acknowledged.en_US
dc.identifier.doi10.1016/j.jorganchem.2016.06.002
dc.identifier.endpage128en_US
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-84977277845
dc.identifier.scopusqualityQ2
dc.identifier.startpage120en_US
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2016.06.002
dc.identifier.urihttps://hdl.handle.net/11468/15726
dc.identifier.volume819en_US
dc.identifier.wosWOS:000382199000016
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal of Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIridium(Iii)en_US
dc.subjectMonodendate Ferrocenyl-Phosphiniteen_US
dc.subjectHomogeneous Catalysisen_US
dc.subjectAsymmetric Transfer Hydrogenationen_US
dc.subjectKetonesen_US
dc.titleEnantioselective transfer hydrogenation of various ketones with novel efficient iridium(III) ferrocenyl-phosphinite catalystsen_US
dc.titleEnantioselective transfer hydrogenation of various ketones with novel efficient iridium(III) ferrocenyl-phosphinite catalysts
dc.typeArticleen_US

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