Antioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approach

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dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorMokaddem-Daroui, Habiba
dc.contributor.authorMostefa, Maya Belhadj
dc.contributor.authorAydoğmuş-Öztürk, Fatma
dc.contributor.authorErol, Ebru
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdulselam
dc.contributor.authorDuru, Mehmet Emin
dc.contributor.authorKabouche, Ahmed
dc.contributor.authorKabouche, Zahia
dc.date.accessioned2021-06-16T08:39:05Z
dc.date.available2021-06-16T08:39:05Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bililmleri Bölümüen_US
dc.descriptionWOS:000654041800001
dc.description.abstractThe fractions (Fr.1-5) of the hydromethanolic extract of Abies numidica cones were studied for their polyphenol constituents, antioxidant, and anticholinesterase activities. The beta-carotene-linoleic acid, cupric reducing power (CUPRAC), DPPH scavenging, and ABTS radical scavenging assays were used to determine antioxidant activity. Fr.3 exhibited the highest antioxidant activity in ABTS test (IC50: 1.29 mu g/mL), b-carotene-linoleic acid test (IC50: 18.6 mu g/mL) and CUPRAC (A(0.5): 33.8 mu g/mL) assays. Three fractions (Fr.2-4) promising antioxidant activity were analyzed using LC-MS/MS for their phenolic compositions. Taxifolin (155.9-2816.2 mu g analyte/g extract), hyperoside (353.0-2045.5 mu g/g), vanillin (1488.9-1529.9 mu g/g), tannic acid (1281.6-1416.8 mu g/g), rosmarinic acid (1063.1-1149.3 mu g/g), coumarin (683.0-772.6 mu g/g), quercetin (881.0 mu g/g), and catechin (277.7-400.2 mu g/g) were identified in the antioxidant fractions. Moreover, the anticholinesterase activity was also performed using the in vitro spectroscopic Ellman method. The antioxidant fractions exhibited moderate butyrylcholinesterase inhibitory activity. The multi-ware analysis was performed to understand the origin of bioactivities. According to principal component analysis, it is detected that the hyperoside, catechin, taxifolin, and tannic acid were responsible for the antioxidant activity. Therefore, the cones of Abies numidica can be considered as potent antioxidant and anticholinesterase sources in food and pharmaceutical industries, commercially.en_US
dc.identifier.citationMokaddem-Daroui, H., Mostefa, M.B., Aydoğmuş-Öztürk, F., Erol, E., Öztürk, M., Ertaş, A. ve diğerleri. (2021). Antioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approach. Journal of Research in Pharmacy, 25(3), 230-237.en_US
dc.identifier.doi10.29228/jrp.13
dc.identifier.endpage237en_US
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85107156754
dc.identifier.scopusqualityQ3
dc.identifier.startpage230en_US
dc.identifier.urihttp://jrespharm.com/uploads/pdf/pdf_MPJ_885.pdf
dc.identifier.urihttps://hdl.handle.net/11468/7112
dc.identifier.volume25en_US
dc.identifier.wosWOS:000654041800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorErtaş, Abdulselam
dc.language.isoenen_US
dc.publisherMarmara Universityen_US
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbies numidicaen_US
dc.subjectLC-MS/MSen_US
dc.subjectAntioxidant activityen_US
dc.subjectAnticholinesterase activityen_US
dc.subjectTaxifolinen_US
dc.subjectHyperosideen_US
dc.titleAntioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approachen_US
dc.titleAntioxidant, anticholinesterase activities and polyphenolic constituents of cones of algerian fir (Abies numidica) by LC-ESI-MS/MS with chemometric approach
dc.typeArticleen_US

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