A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)

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dc.contributor.authorBoukeloua, Ahmed
dc.contributor.authorLeila, Soudani
dc.contributor.authorBendif, Hamdi
dc.contributor.authorElkadeem, Ahmed Mustafa
dc.contributor.authorBoğa, Mehmet
dc.contributor.authorSerralheiro, Maria Luísa
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorYener, İsmail
dc.date.accessioned2024-04-24T17:56:10Z
dc.date.available2024-04-24T17:56:10Z
dc.date.issued2024
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe study aimed to analyse the chemical and biological composition of Azadirachta indica (A. Juss) (A. indica) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds and water-soluble vitamins were identified via LC-MS/MS. Antioxidant activity was assessed using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC), while anticholinesterase effect was tested against butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE). Results revealed significant levels of major elements (e.g., Zn, Cu) making it a promising source. Predominant phenolic acids included tannic and salicylic acid, with major flavonoids being hyperoside, kaempferol, and quercetin. Main water-soluble vitamins were nicotinic acid, nicotinamide, and pantothenic acid, followed by pyridoxine, thiamine, and riboflavin. Ethanol extract exhibited moderate antioxidant activity (30.02 % inhibition of ABTS radicals; IC50 0.918 ?g/mL for CUPRAC and low inhibition of BChE and AChE (2.29 % and 3.17 % respectively). These findings highlight A. indica as a valuable natural source of nutritionally significant compounds and antioxidants. © 2024 Phytochemical Society of Europeen_US
dc.identifier.citationBoukeloua, A., Leila, S., Bendif, H., Elkadeem, A. M., Boğa, M., Serralheiro, M. L. ve diğerleri. (2024). A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss). Phytochemistry Letters, 61, 89-96.
dc.identifier.doi10.1016/j.phytol.2024.03.017
dc.identifier.endpage96en_US
dc.identifier.issn1874-3900
dc.identifier.scopus2-s2.0-85189766053
dc.identifier.scopusqualityQ2
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1016/j.phytol.2024.03.017
dc.identifier.urihttps://hdl.handle.net/11468/23342
dc.identifier.volume61en_US
dc.indekslendigikaynakScopus
dc.institutionauthorBoğa, Mehmet
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorYener, İsmail
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofPhytochemistry Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBioactivityen_US
dc.subjectChemical analysesen_US
dc.subjectPhenolic compoundsen_US
dc.subjectWater soluble vitaminsen_US
dc.titleA comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)en_US
dc.titleA comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)
dc.typeArticleen_US

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