A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss)
Yükleniyor...
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The study aimed to analyse the chemical and biological composition of Azadirachta indica (A. Juss) (A. indica) leaves. Minerals were quantified using inductively coupled plasma-mass spectrometry (ICP-MS). Phenolic compounds and water-soluble vitamins were identified via LC-MS/MS. Antioxidant activity was assessed using ABTS cation radicals and cupric reducing antioxidant capacity (CUPRAC), while anticholinesterase effect was tested against butyrylcholinesterase (BChE) and Acetylcholinesterase (AChE). Results revealed significant levels of major elements (e.g., Zn, Cu) making it a promising source. Predominant phenolic acids included tannic and salicylic acid, with major flavonoids being hyperoside, kaempferol, and quercetin. Main water-soluble vitamins were nicotinic acid, nicotinamide, and pantothenic acid, followed by pyridoxine, thiamine, and riboflavin. Ethanol extract exhibited moderate antioxidant activity (30.02 % inhibition of ABTS radicals; IC50 0.918 ?g/mL for CUPRAC and low inhibition of BChE and AChE (2.29 % and 3.17 % respectively). These findings highlight A. indica as a valuable natural source of nutritionally significant compounds and antioxidants. © 2024 Phytochemical Society of Europe
Açıklama
Anahtar Kelimeler
Bioactivity, Chemical analyses, Phenolic compounds, Water soluble vitamins
Kaynak
Phytochemistry Letters
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
61
Sayı
Künye
Boukeloua, A., Leila, S., Bendif, H., Elkadeem, A. M., Boğa, M., Serralheiro, M. L. ve diğerleri. (2024). A comprehensive study on chemical and biological profiles of Algerian Azadirachta indica (A. Juss). Phytochemistry Letters, 61, 89-96.
