Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats

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dc.contributor.authorCanoruc N.
dc.contributor.authorUlak G.
dc.contributor.authorGuzel C.
dc.contributor.authorKaya H.
dc.contributor.authorCicek R.
dc.date.accessioned2024-04-24T18:44:08Z
dc.date.available2024-04-24T18:44:08Z
dc.date.issued1994
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.en_US
dc.identifier.endpage5en_US
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0027936047
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/11468/24571
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFamotidineen_US
dc.subjectNitrendipineen_US
dc.subjectOmeprazoleen_US
dc.subjectStress Ulceren_US
dc.titlePreventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in ratsen_US
dc.titlePreventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats
dc.typeArticleen_US

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