Preventive action of omeprazole, famotidine or nitrendipine against stress ulcer formation in rats
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Tarih
1994
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The effects of H+/K+-ATP ase inhibitor, omeprazole, the H2-receptor antagonist, famotodine, and the calcium channel antagonist, nitrendipine, on gastric ulcers, gastric mucosal barrier and gastrin release were investigated in cold-restraint stress-induced rats. Omeprazole (30 mg/kg i.g.) famotidine (1 mg/kg, i.g.) and nitrendipine (16 mg/kg, i.p.) significantly prevented gastric ulceration. Nitrendipine reduced the mucus secretion and exhibited no important change in phospholipid content; thus, it failed to restore the damage in the gastric mucosal barrier due to cold-restraint stress. Omeprazole increased mucus secretion and phospholipid content of gastric mucosal barrier whereas famotidine tended to cause an increase in mucus and phospholipid levels; however, this difference did not attain statistical significance. Serum gastrin levels revealed lower values in the nitrendipine group as compared with controls; whereas it increased in omeprazole and famotidine groups, but more significantly in the omeprazole treated group.
Açıklama
Anahtar Kelimeler
Famotidine, Nitrendipine, Omeprazole, Stress Ulcer
Kaynak
Turkish Journal of Medical Sciences
WoS Q Değeri
Scopus Q Değeri
Q1
Cilt
22
Sayı
1
