Synthesis and characterisation of novel 4,6-dimethoxyindole-7-and-2-thiosemicarbazone derivatives: Biological evaluation as antioxidant and anticholinesterase candidates

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dc.contributor.authorBingul, Murat
dc.date.accessioned2024-04-24T17:14:45Z
dc.date.available2024-04-24T17:14:45Z
dc.date.issued2019
dc.departmentDicle Üniversitesien_US
dc.description.abstractTwo sets of novel indole-based thiosemicarbazone systems 8a-d and 9a-d are prepared by the Schiff base condensation reaction of indole carbaldehydes 4 and 6 with a range of thiosemicarbazides 7a-d in high yields and purity. The antioxidant properties of the synthesised compounds 8a-d and 9a-d are determined by employing three different assays, namely 2,2-diphenyl-1-picrylhydrazyl hydrate-free radical scavenging, ABTS [2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] cationic radical decolarization and cupric ion reducing antioxidant capacity. The anticholinesterase properties of the products are investigated by acetylcholinesterase and butyrylcholinesterase enzyme inhibition assays. The methyl-substituted compounds 8b and 9b display the highest inhibition for the ABTS assay and absorbance values for the cupric ion reducing antioxidant capacity assay, while compound 9c shows the best activity for 2,2-diphenyl-1-picrylhydrazyl hydrate assay. Moderate inhibition of acetylcholinesterase and butyrylcholinesterase is determined in the case of compound 8b.en_US
dc.identifier.doi10.1177/1747519819868386
dc.identifier.endpage406en_US
dc.identifier.issn1747-5198
dc.identifier.issn2047-6507
dc.identifier.issue9-10en_US
dc.identifier.scopus2-s2.0-85071436164
dc.identifier.scopusqualityQ3
dc.identifier.startpage399en_US
dc.identifier.urihttps://doi.org/10.1177/1747519819868386
dc.identifier.urihttps://hdl.handle.net/11468/18176
dc.identifier.volume43en_US
dc.identifier.wosWOS:000490982700013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal of Chemical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectDimethoxyindoleen_US
dc.subjectHemetsberger Indole Synthesisen_US
dc.subjectThiosemicarbazoneen_US
dc.titleSynthesis and characterisation of novel 4,6-dimethoxyindole-7-and-2-thiosemicarbazone derivatives: Biological evaluation as antioxidant and anticholinesterase candidatesen_US
dc.titleSynthesis and characterisation of novel 4,6-dimethoxyindole-7-and-2-thiosemicarbazone derivatives: Biological evaluation as antioxidant and anticholinesterase candidates
dc.typeArticleen_US

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