Valproate Induced Hypoactive Delirium in a Bipolar Disorder Patient with Psychotic Features

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dc.contributor.authorOzen, Sakir
dc.contributor.authorBulbul, Israfil
dc.contributor.authorSoyucok, Etem
dc.date.accessioned2024-04-24T17:44:48Z
dc.date.available2024-04-24T17:44:48Z
dc.date.issued2010
dc.departmentDicle Üniversitesien_US
dc.description.abstractDelirium may present with hyperactive, hypoactive or mixed clinical pictures. The signs of hypoactive delirium Ore lethargy, confusion, apathy, hypersomnia, muttering, difficulty in maintaining attention, and difficulty in understanding and performing commands. Valproate is commonly used for the treatment of epilepsy and bipolar disorders. It is also used for the management of alcohol withdrawal delirium and agitative-aggressive deliriums. However few reports are available about the valproate-induced delirium. In this report, we present a 46 years-old woman with bipolar disorder for 14 years. During her lost two hospital admissions, she had been diagnosed with manic episode with psychotic features and she had received valproate. She experienced three hypoactive delirium episodes lasting 2-3 days throughout the treatment period of first week. The patient predominantly had the following signs; vomiting, hypersalivation, confusion, drowsiness, dysphasia, and hypoactivity. At the first day of delirium episode, serum valproate level was found to be within the therapeutic range (98.4, 117.1, and 65.6 mu g/ml, respectively). In addition, she had normal results of cranial MRI, complete blood count, urine analysis, electrocardiogram, ALT, AST albumin, bilirubin, BUN, creatinine and electrolytes. The serum ammonia level of the patient could not been measured due to limitations of laboratory facilities. The patient's consciousness improved dramatically 2-3 days after cessation of valproate. In conclusion, valproate can induce delirium at therapeutic blood levels in some patients via various mechanisms and this side effect has to be considered during valproate use.en_US
dc.identifier.endpage84en_US
dc.identifier.issn1300-2163
dc.identifier.issue1en_US
dc.identifier.pmid20204907
dc.identifier.startpage79en_US
dc.identifier.urihttps://hdl.handle.net/11468/22293
dc.identifier.volume21en_US
dc.identifier.wosWOS:000275732100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isotren_US
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectValproateen_US
dc.subjectHypoactive Deliriumen_US
dc.titleValproate Induced Hypoactive Delirium in a Bipolar Disorder Patient with Psychotic Featuresen_US
dc.titleValproate Induced Hypoactive Delirium in a Bipolar Disorder Patient with Psychotic Features
dc.typeArticleen_US

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