Poor immune response to hepatitis B vaccination in hemodialysis patients

Basit Öğe Kaydı
dc.contributor.authorYazanel O.
dc.contributor.authorCanoruc F.
dc.contributor.authorIsikoglu B.
dc.date.accessioned2024-04-24T17:58:55Z
dc.date.available2024-04-24T17:58:55Z
dc.date.issued1996
dc.departmentDicle Üniversitesien_US
dc.description.abstractFor active immunization against infection caused by hepatitis B virus, 25 hemodialysis patients (13 men, 12 women, 15-62 years old range) were vaccinated with the close of 20-40 microgram recombinant DNA vaccine, three times one month apart. At the first evaluation 2 months after the last vaccination, we were able to include in the study 24 hemodialysis patients and 27 healthy relatives. Of 24 hemodialysis patients, 14 (58.3%) and of 27 healthy relatives, 25 (93%) developed anti-HBs antibody. Six months after the last vaccination (second evaluation), two men more had anti-HBs antibody. Thus, totally 16 hemodialysis patients responded to hepatitis B vaccination (66.6%). Immune reactivity seems to correlate with the uremic (p<0.05) and nutritional status. Women were more likely (75%) to be responder than men (50%), and the younger patients (<40 years old) correlated significantly with the antibody response. In conclusion, since these patients had a poor antibody response to standard vaccination, alternative hepatitis B vaccination regimens may have to be planned in this particular group of patients.en_US
dc.identifier.endpage135en_US
dc.identifier.issn1300-4948
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0029950161en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://hdl.handle.net/11468/24155
dc.identifier.volume7en_US
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.relation.ispartofTurkish Journal of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnti-Hbs Antibodyen_US
dc.subjectChronic Hemodialysis Patientsen_US
dc.subjectHepatitis B (Hb) Vaccinationen_US
dc.titlePoor immune response to hepatitis B vaccination in hemodialysis patientsen_US
dc.title.alternativeHEMODIALIZ HASTALARINDA HEPATITIS B ASILAMASINA ZAYIF IMMUN YANITen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu