Poor immune response to hepatitis B vaccination in hemodialysis patients
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Tarih
1996
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
For active immunization against infection caused by hepatitis B virus, 25 hemodialysis patients (13 men, 12 women, 15-62 years old range) were vaccinated with the close of 20-40 microgram recombinant DNA vaccine, three times one month apart. At the first evaluation 2 months after the last vaccination, we were able to include in the study 24 hemodialysis patients and 27 healthy relatives. Of 24 hemodialysis patients, 14 (58.3%) and of 27 healthy relatives, 25 (93%) developed anti-HBs antibody. Six months after the last vaccination (second evaluation), two men more had anti-HBs antibody. Thus, totally 16 hemodialysis patients responded to hepatitis B vaccination (66.6%). Immune reactivity seems to correlate with the uremic (p<0.05) and nutritional status. Women were more likely (75%) to be responder than men (50%), and the younger patients (<40 years old) correlated significantly with the antibody response. In conclusion, since these patients had a poor antibody response to standard vaccination, alternative hepatitis B vaccination regimens may have to be planned in this particular group of patients.
Açıklama
Anahtar Kelimeler
Anti-Hbs Antibody, Chronic Hemodialysis Patients, Hepatitis B (Hb) Vaccination
Kaynak
Turkish Journal of Gastroenterology
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
7
Sayı
2
