Is Cranial Imaging Necessary in Girls Between 6-8 Years Diagnosed with Central Precocious Puberty?

dc.contributor.authorBestas, Asli
dc.contributor.authorUnal, Edip
dc.contributor.authorKarakaya, Amine Aktar
dc.contributor.authorHaspolat, Yusuf Kenan
dc.date.accessioned2024-04-24T17:18:49Z
dc.date.available2024-04-24T17:18:49Z
dc.date.issued2021
dc.departmentDicle Üniversitesien_US
dc.description.abstractAim: There is no clear consensus on whether a cranial MRI should be performed in all cases of central precocious puberty(CPP). In this study, we aimed at evaluating the incidence of intracranial lesions and analyzing cranial imaging results in females with CPP Methods: In the retrospective study medical records of the case, the age at the time of admission, anthropometric measurements, bone age, Tanner stages, serum follicle-stimulating hormone (FSH), serum luteinizing hormone(LH), serum estradiol (E2) levels, the peak LH level during the gonadotropin-releasing hormone (GnRH) stimulation test and the cranial MRI findings at the time of the diagnosis of CPP were collected. Results: The mean age diagnosis of the 154 girls included in the study was 6.9 +/- 1.08. Nine (5.8%) of 154 patients were diagnosed with organic-caused CPP. Four of the nine cases diagnosed with organic CPP had a previously known CNS pathology. The other five cases did not have any neurological findings at the time of diagnosis. Incidental lesions were detected at cranial MRI of nine of the 145 cases diagnosed with idiopathic CPP. The basal E2, basal LH, basal FSH, peak LH and peak LH/FSH levels of the cases with organic CPP were higher than those with idiopathic CPP. Conclusion: In our study, approximately 90% of organic CPP due to intracranial lesions were between 6-8 years. Therefore, we believe that cranial imaging should be performed in all females with CPP.en_US
dc.identifier.doi10.23736/S2724-6507.21.03621-6
dc.identifier.issn2724-6507
dc.identifier.issn2724-6116
dc.identifier.pmid34546020
dc.identifier.urihttps://doi.org/10.23736/S2724-6507.21.03621-6
dc.identifier.urihttps://hdl.handle.net/11468/18918
dc.identifier.wosWOS:001162915800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Endocrinology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCentral Precocious Pubertyen_US
dc.subjectCranial Mrien_US
dc.subjectCns Anomaliesen_US
dc.titleIs Cranial Imaging Necessary in Girls Between 6-8 Years Diagnosed with Central Precocious Puberty?en_US
dc.titleIs Cranial Imaging Necessary in Girls Between 6-8 Years Diagnosed with Central Precocious Puberty?
dc.typeArticleen_US

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