Synthesis of cysteine modified MoS2 nanocomposite: A biocompatible electrochemical sensor material and its application to the determination of antidiabetic dapagliflozin

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dc.contributor.authorAteş, Ali Kemal
dc.contributor.authorÇelikkan, Hüseyin
dc.contributor.authorErk, Nevin
dc.contributor.orcid0000-0002-5846-4436
dc.contributor.orcid0000-0002-8016-3082
dc.contributor.orcid0000-0001-5366-9275
dc.date.accessioned2024-04-24T15:59:23Z
dc.date.available2024-04-24T15:59:23Z
dc.date.issued2020
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractHerein, for the first time, a new generation cysteine modified MoS2(Cys@MoS2) based electrochemical sensor was reported. The electrochemical behaviour of dapagliflozin (DAP) was investigated through differential pulse voltammetry (DPV) on the developed sensor (Cys@MoS2/GCE). The transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), x-ray diffraction spectroscopy (XRD) and x-ray photoelectron spectroscopy (XPS) methods were performed for structural and morphological characterizations of Cys@MoS(2)nanocomposite. On the surface of Cys@MoS2/GCE, an irreversible anodic peak was observed at 1324 mV. Under the optimal conditions, linear calibration curve with two working ranges between 2.0-60.0 mu M and 60.0-110.0 mu M were obtained and limit of detection was found to be 1.6 mu M. The developed sensor was successfully applied to determine the content of DAP in pharmaceutical sample with satisfying recovery results. It is concluded that Cys@MoS2/GCE is a reliable, easy to apply and cost-effective sensor for the routine DAP analysis in pharmaceutical samples.en_US
dc.identifier.citationAteş, A. K., Çelikkan, H. ve Erk, N. (2020). Synthesis of cysteine modified MoS2 nanocomposite: A biocompatible electrochemical sensor material and its application to the determination of antidiabetic dapagliflozin. Electroanalysis, 32(7), 1480-1487.
dc.identifier.doi10.1002/elan.202000044
dc.identifier.endpage1487en_US
dc.identifier.issn1040-0397
dc.identifier.issn1521-4109
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85083178117
dc.identifier.scopusqualityQ2
dc.identifier.startpage1480en_US
dc.identifier.urihttps://doi.org/10.1002/elan.202000044
dc.identifier.urihttps://hdl.handle.net/11468/14033
dc.identifier.urihttps://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202000044
dc.identifier.volume32en_US
dc.identifier.wosWOS:000547982900010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAteş, Ali Kemal
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofElectroanalysis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMolybdenum disulphideen_US
dc.subjectCysteineen_US
dc.subjectDifferential pulse voltammetryen_US
dc.subjectDapagliflozinen_US
dc.subjectDeterminationen_US
dc.titleSynthesis of cysteine modified MoS2 nanocomposite: A biocompatible electrochemical sensor material and its application to the determination of antidiabetic dapagliflozinen_US
dc.titleSynthesis of cysteine modified MoS2 nanocomposite: A biocompatible electrochemical sensor material and its application to the determination of antidiabetic dapagliflozin
dc.typeArticleen_US

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