PREVALENCE OF FACTOR XIII VAL34LEU POLYMORPHISM IN THROMBOSIS CASES IN THE SOUTHEAST OF TURKEY AND ITS CORRELATION WITH THROMBOSIS

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dc.contributor.authorYildirim, Mehmet Serdar
dc.contributor.authorDal, Mehmet Sinan
dc.contributor.authorKarakus, Abdullah
dc.contributor.authorOto, Ferhat
dc.contributor.authorGoruk, Mucahit
dc.contributor.authorAkdogan, Mehmet Recai
dc.contributor.authorNas, Necib
dc.date.accessioned2024-04-24T17:18:22Z
dc.date.available2024-04-24T17:18:22Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: Thrombosis is triggered by a shift in the balance of procoagulant and anticoagulant factors due to acquired or inherited causes. Factor XIII plays an important role in the stabilization of the linkage between fibrins. Three different genetic structure of Valine34Leucine polymorphism in FXIIIA have been described. Valine/Valine structure has been identified as the homozygous normal (wild-type), whereas Valine/Leucine and Leucine/Leucine structures have been identified as heterozygous and homozygous mutants respectively. Genetic polymorphisms in FXIII-A subunit vary substantially from society to society. The primary objective of this study was to determine the relationship between factor XIII polymorphisms and arterial/venous thromboembolism in the southeast of Turkey. Methods: A total of 127 patients with arterial and venous thrombosis were included as the study group and 102 healthy subjects with no thromboembolic disorders were included as the control group. Val34Leu polymorphism in FXIII was investigated in both groups using PCR (Polymerase chain reaction). Results: The prevalence of the polymorphism in the study and control groups were compared with chi-square test, no statistically significant differences were found (the prevalence in the study and control group are 68.5% and 66.7% for V/V allele, 29.2% and 29.4% for V/L allele, and 2.4% and 3.9% in L/L allele respectively, with p = 0.787). When deep vein thrombosis (DVT) diagnosed female patients group (n = 8) was compared to the healthy female control group, V/L allele was significantly lower, whereas L/L allele was significantly higher (p = < 0.01). Conclusions: This study indicates that there is no evidence for association between factor XIII-A Val34Leu polymorphism and arterial/venous thromboembolism. The significant result we found for the DVT patients should be strengthened by further studies with greater number of cases. In future, further studies are needed with more specific groups and with greater numbers of patients.en_US
dc.identifier.doi10.19193/0393-6384_2017_1_013
dc.identifier.endpage87en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85013178108
dc.identifier.scopusqualityN/A
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2017_1_013
dc.identifier.urihttps://hdl.handle.net/11468/18753
dc.identifier.volume33en_US
dc.identifier.wosWOS:000397226800013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterranea
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFactor Xiiien_US
dc.subjectPolymorphismen_US
dc.subjectThrombophiliaen_US
dc.subjectVenous-Arterial Thrombosisen_US
dc.titlePREVALENCE OF FACTOR XIII VAL34LEU POLYMORPHISM IN THROMBOSIS CASES IN THE SOUTHEAST OF TURKEY AND ITS CORRELATION WITH THROMBOSISen_US
dc.titlePREVALENCE OF FACTOR XIII VAL34LEU POLYMORPHISM IN THROMBOSIS CASES IN THE SOUTHEAST OF TURKEY AND ITS CORRELATION WITH THROMBOSIS
dc.typeArticleen_US

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