The effects of pulsed and sinusoidal electromagnetic fields on E-cadherin and type IV collagen in gingiva: A histopathological and immunohistochemical study

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dc.contributor.authorDogru A.G.
dc.contributor.authorTunik S.
dc.contributor.authorAkpolat V.
dc.contributor.authorDogru M.
dc.contributor.authorSaribas E.E.
dc.contributor.authorKaya F.A.
dc.contributor.authorNergiz Y.
dc.date.accessioned2024-04-24T18:45:48Z
dc.date.available2024-04-24T18:45:48Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground. The potential beneficial effects of extremely low frequency pulsed and sinusoidal electromagnetic fields have been shown on many tissues. Gingival epithelium plays an important role in immunosurveillance of the periodontal tissues. The epithelium acts as a mechanical barrier through cell junctions such as E-cadherin. Objectives. Investigation of the effects of extremely low frequency magnetic fields on gingiva. Material and Methods. Twenty-seven male Wistar albino rats were used. The rats were divided into three groups: control group (n = 9), SEMF group (n = 9), PEMF group (n = 9). The SEMF and PEMF (pulse time: 25 ?sn, pulse frequency: 50 Hz) groups were subjected to 1.5 mT, 50 Hz, exposure 6 h a day, 5 days a week for 28 days in methacrylate boxes. The gingival tissue pieces processed for routine histological and immunohistochemical examination and tissue sections were stained with H-E and Masson trichrome. In addition, E-cadherin and type IV collagen expressions were examined immunohistochemically. Results. Intraepithelial lymphocytes and proliferation of epithelial cells increased in both electromagnetic field groups. The over-expressions of E-cadherin on gingival epithelium was detected in the PEMF and SEMF groups. The expression level of type IV collagen was not significant between the control and electromagnetic field treated groups, except for a significant increase in the basal cell layer of the PEMF group, as compared to the control and SEMF groups. Conclusions. PEMF and SEMF have a local pro-inflammatory effect on gingiva, leading to an increase in E-cadherin level but not type IV collagen. Both PEMF and SEMF can be used as a supportive device in the treatment of gingival diseases, especially those which lead to defects in the epithelial barrier. © Copyright by Wroclaw Medical University.en_US
dc.identifier.endpage252en_US
dc.identifier.issn1899-5276
dc.identifier.issue2en_US
dc.identifier.pmid23709381
dc.identifier.scopus2-s2.0-84878631971
dc.identifier.scopusqualityQ1
dc.identifier.startpage245en_US
dc.identifier.urihttps://hdl.handle.net/11468/24887
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWroclaw University of Medicineen_US
dc.relation.ispartofAdvances in Clinical and Experimental Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectE-Cadherinen_US
dc.subjectHistopathologyen_US
dc.subjectPulsed And Sinusoidal Electromagnetic Fieldsen_US
dc.subjectType Iv Collagenen_US
dc.titleThe effects of pulsed and sinusoidal electromagnetic fields on E-cadherin and type IV collagen in gingiva: A histopathological and immunohistochemical studyen_US
dc.titleThe effects of pulsed and sinusoidal electromagnetic fields on E-cadherin and type IV collagen in gingiva: A histopathological and immunohistochemical study
dc.typeArticleen_US

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