Investigation of Mean Platelet Volume in Patients with Multiple Sclerosis

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dc.contributor.authorUzar, Ertugrul
dc.contributor.authorArikanoglu, Adalet
dc.contributor.authorYucel, Yavuz
dc.contributor.authorAydin, Birsen
dc.contributor.authorTanriverdi, Mehmet Halis
dc.contributor.authorTasdemir, Nebahat
dc.date.accessioned2024-04-24T17:37:34Z
dc.date.available2024-04-24T17:37:34Z
dc.date.issued2011
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Alterations in platelet function have been observed in patients with multiple sclerosis. Mean platelet volume is a marker of the platelet activity and is reported to be increased in vascular diseases. The aim of this retrospective study was to investigate the correlation between mean platelet volume and multiple sclerosis. Materials and Methods: The patient group consisted of 46 multiple sclerosis patients who were presented with multiple sclerosis attacks (males/females: 10/36, mean age: 34.3 +/- 9.4 year). In the multiple sclerosis patients, mean platelet volume values during the attack were compared with the mean platelet volume value after attack. Mean platelet volume values of patients were also compared with those of 38 age/sex-matched healthy individuals (males/females: 14/24, mean age: 36.4 +/- 10.4). Results: No difference was found in mean platelet volume values during the multiple sclerosis attack (8.0 +/- 1.2) versus after the multiple sclerosis attack (7.9 +/- 1.2), and no relation was found between mean platelet volume and Expanded Disability Status Scale (EDSS) parameters (p> 0.05). No difference was found in mean platelet volume values between the multiple sclerosis group (8.1 +/- 1.3) and control group (8.1 +/- 1.1) (p> 0.05). Conclusion: No significant change in mean platelet volume values was seen during the multiple sclerosis attack versus after the multiple sclerosis attack. This finding supports that platelet activation does not play an important role in the multiple sclerosis pathogenesis. However, the relation between multiple sclerosis and mean platelet volume should be investigated prospectively.en_US
dc.identifier.endpage188en_US
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84855575517
dc.identifier.scopusqualityQ4
dc.identifier.startpage185en_US
dc.identifier.urihttps://hdl.handle.net/11468/21032
dc.identifier.volume17en_US
dc.identifier.wosWOS:000217526000004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotren_US
dc.publisherTurkish Neurological Socen_US
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectPlatelet Activationen_US
dc.subjectPlateletsen_US
dc.titleInvestigation of Mean Platelet Volume in Patients with Multiple Sclerosisen_US
dc.titleInvestigation of Mean Platelet Volume in Patients with Multiple Sclerosis
dc.typeArticleen_US

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