Chromosomal abnormalities in non-obstructive azoospermic men prior to employment of assisted reproduction in Southeast Turkey

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dc.contributor.authorBalkan M.
dc.contributor.authorAtar M.
dc.contributor.authorKemal Hatipo?lu N.
dc.contributor.authorNuri Bodakçi M.
dc.contributor.authorÇakmakçi S.
dc.contributor.authorYildiz I.
dc.contributor.authorSiddik Evsen M.
dc.date.accessioned2024-04-24T18:46:02Z
dc.date.available2024-04-24T18:46:02Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: The causes of male infertility are heterogeneous but more than 50% of cases have a genetic defect. Chromosomal abnormalities that affect on gametogenesis are one of the principle genetic factors in male infertility. The aim of this study is to determine the frequency and type of chromosomal abnormalities in non-obstructive azoospermic men with severe male factor infertility to give appropriate genetic counseling before assisted reproduction techniques. Materials and Methods: A total of 114 azoospermic infertile males were studied for the cytogenetic evaluation prior to use of assisted reproduction techniques. A detailed history was taken for each man. Karyotyping was performed on peripheral blood lymphocytes according to standard methods. Results: The overall incidence of chromosomal abnormalities was about 22.8% (26/114), including the sex chromosome abnormality 19.3% and the autosomal chromosome abnormality 3.5%. Twenty one of 22 patients with sex chromosome abnormality had classic Klinefelter karyotype. There were 2 mosaic cases involving X and Y chromosomes. Of the four cases with autosomal chromosome anomalies, three cases had balanced reciprocal translocations and one case with inversion. FSH, LH and testosterone levels showed significant increase in azoospermic patients with abnormal karyotype when compared with the normal karyotype (P < 0.05). Conclusions: Our findings are generally in accordance with those from other surveys and confirm that the XXY aneuploidy is the most frequent chromosomal abnormality in azoospermic individuals. The occurrence of chromosomal anomalies among infertile males suggests the need for genetic screening and proper genetic counselling before initiation of assisted reproduction treatment. © 2015 Japan Health Sciences University.en_US
dc.identifier.endpage303en_US
dc.identifier.issn1341-2051
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-84949511658
dc.identifier.scopusqualityN/A
dc.identifier.startpage299en_US
dc.identifier.urihttps://hdl.handle.net/11468/25030
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherJapan International Cultural Exchange Foundationen_US
dc.relation.ispartofInternational Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAssisted Reproduction Techniquesen_US
dc.subjectAzoospermiaen_US
dc.subjectChromosomeen_US
dc.subjectKaryotype Analysisen_US
dc.subjectMale İnfertilityen_US
dc.titleChromosomal abnormalities in non-obstructive azoospermic men prior to employment of assisted reproduction in Southeast Turkeyen_US
dc.titleChromosomal abnormalities in non-obstructive azoospermic men prior to employment of assisted reproduction in Southeast Turkey
dc.typeArticleen_US

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