Effects of caffeic acid phenethyl ester on cisplatin ototoxicity

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dc.contributor.authorOzbay, M.
dc.contributor.authorSengul, E.
dc.contributor.authorKinis, V.
dc.contributor.authorAlabalik, U.
dc.contributor.authorYilmaz, B.
dc.contributor.authorTopcu, I.
dc.date.accessioned2024-04-24T17:40:07Z
dc.date.available2024-04-24T17:40:07Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To report histological and electrophysiological data in rats treated with cisplatin and caffeic acid phenethyl ester. Methods: We randomly divided 28 Wistar rats into four groups of seven, to be treated as follows: control (saline), cisplatin, CAPE and cisplatin-CAPE. Distortion product otoacoustic emission (DPOAE) measurements were performed on day one (before drug administration) and day five under anaesthesia. All animals were killed under general anaesthesia on day five after the DPOAE measurement. The cochleae of each rat were histopathologically and immunohistochemically evaluated. Results: The outer hair cells were mostly preserved in the control and CAPE groups. Moderate -to -severe and mild -to moderate hair cell losses were detected in the cisplatin and cisplatin-CAPE groups, respectively. DPOAE assessments revealed significant deterioration in the cisplatin group (P < 0.05). The difference between the cisplatin and cisplatin-CAPE groups was statistically significant (P < 0.05). Conclusion: CAPE prevents cisplatin ototoxicityen_US
dc.identifier.endpage218en_US
dc.identifier.issn1781-782X
dc.identifier.issue3en_US
dc.identifier.pmid29727126
dc.identifier.startpage211en_US
dc.identifier.urihttps://hdl.handle.net/11468/21619
dc.identifier.volume12en_US
dc.identifier.wosWOS:000387634400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherRoyal Belgian Soc Ear, Nose, Throat, Head & Neck Surgeryen_US
dc.relation.ispartofB-Ent
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCisplatinen_US
dc.subjectCaffeic Acid Phenethyl Esteren_US
dc.subjectOtotoxicityen_US
dc.subjectOtoacoustic Emissionen_US
dc.subjectRaten_US
dc.titleEffects of caffeic acid phenethyl ester on cisplatin ototoxicityen_US
dc.titleEffects of caffeic acid phenethyl ester on cisplatin ototoxicity
dc.typeArticleen_US

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