Can elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?

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dc.contributor.authorYavuz, Celal
dc.contributor.authorGuclu, Orkut
dc.contributor.authorDemirtas, Sinan
dc.contributor.authorKarahan, Oguz
dc.contributor.authorYazici, Suleyman
dc.contributor.authorCaliskan, Ahmet
dc.contributor.authorCelik, Yusuf
dc.date.accessioned2024-04-24T17:28:00Z
dc.date.available2024-04-24T17:28:00Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground: This study aims to determine the relationship between serum prolidase activity and ischemia duration in different ischemia types. Methods: Forty male Sprague Dawley rats were divided into five equal groups. The rats were sacrificed and blood samples were obtained to determine the basal serum prolidase levels in group 1 (control group) without any intervention. In groups 2 and 3, the superior mesenteric arteries were clamped with simple laparotomy to induce mesenteric ischemia. In groups 4 and 5, the right common femoral artery was clamped to induce peripheral ischemia and blood samples were taken at 120 and at 360 minutes, respectively. The serum prolidase levels were measured using the samples obtained from each group. Results: The basal prolidase level in rats was found to be 266.8 +/- 20.5 U/L. The serum prolidase levels increased after two-hours of peripheral (404.0 +/- 105.6 U/L) and mesenteric ischemia (317.1 +/- 121.4 U/L). However, the serum prolidase levels decreased after six-hours of peripheral (346.1 +/- 104.9 U/L) and mesenteric ischemia (233.4 +/- 36.6 U/L). Although the serum prolidase levels were elevated in the second hour of mesenteric ischemia, they were lower than the enzyme levels obtained after two-hours of peripheral ischemia (p=0.006). Conclusion: The serum prolidase level may be an important predictive biomarker for identifying the duration of ischemia.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2013.7855
dc.identifier.endpage1004en_US
dc.identifier.issn1301-5680
dc.identifier.issue4en_US
dc.identifier.startpage1000en_US
dc.identifier.trdizinid151562
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2013.7855
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/151562
dc.identifier.urihttps://hdl.handle.net/11468/20288
dc.identifier.volume21en_US
dc.identifier.wosWOS:000326410100022
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomarkeren_US
dc.subjectIschemia Durationen_US
dc.subjectMesenteric Ischemiaen_US
dc.subjectPeripheral Ischemiaen_US
dc.subjectProlidase Levelen_US
dc.titleCan elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?en_US
dc.titleCan elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?
dc.typeArticleen_US

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