Phytochemical profile and some biological activities of three Centaurea species from Turkey

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dc.contributor.authorBoga, Mehmet
dc.contributor.authorAlkan, Huseyin
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorOral, Elif Varhan
dc.contributor.authorYilmaz, Mustafa A.
dc.contributor.authorYesil, Yeter
dc.contributor.authorGoren, Ahmet C.
dc.date.accessioned2024-04-24T17:24:35Z
dc.date.available2024-04-24T17:24:35Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractPurpose: To characterise the phytochemical profile of whole plants of Centaurea balsamita, C. depressa and C. lycopifolia with LC-ESI-MS/MS, and as well as their antioxidant, anticholinesterase and antimicrobial activities. Methods: Organic and aqueous extracts of the three Centaurea species were evaluated for DPPH free radical, ABTS cation radical scavenging and cupric reducing antioxidant capacity (CUPRAC). Acetyl-and butyryl-cholinesterase enzyme inhibition abilities of the extracts using petroleum ether, acetone, methanol and water were studied to determine anticholinesterase activity, while antimicrobial activity was determined by disc diffusion method using appropriate antimicrobial standards and organisms. The phytochemical components of the methanol extracts were assessed by LC-MS/MS. Results: The methanol extract of C. balsamita exhibited much higher DPPH free and ABTS cation radicals scavenging activities (with IC50 of 62.65 +/- 0.97 and 24.21 +/- 0.70 mg/ml, respectively) than the other extracts. The petroleum ether extracts of the plant species exhibited moderate inhibitory activity against butyrylcholinesterase enzymes while the acetone extract of C. balsamita showed good antifungal activity against Candida albicans. Quinic acid (17513 +/- 813 mu g/g, 63874 +/- 3066 mu g/g and 108234 +/- 5195 mu g/g) was the major compound found in the methanol extracts of C. balsamita, C. depressa and C. Lycopifolia, respectively. Conclusion: These results indicate quinic acid is the major compound in the three plant species and that Centaurea balsamita has significant antioxidant, anticholinesterase and antimicrobial properties. Further studies to identify the compounds in the extracts responsible for the activities are required.en_US
dc.identifier.doi10.4314/tjpr.v15i9.8
dc.identifier.endpage1875en_US
dc.identifier.issn1596-5996
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-84989332132
dc.identifier.scopusqualityQ3
dc.identifier.startpage1865en_US
dc.identifier.urihttps://doi.org/10.4314/tjpr.v15i9.8
dc.identifier.urihttps://hdl.handle.net/11468/19745
dc.identifier.volume15en_US
dc.identifier.wosWOS:000386951900008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherPharmacotherapy Groupen_US
dc.relation.ispartofTropical Journal of Pharmaceutical Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentaureaen_US
dc.subjectLc-Esi-Ms/Msen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.titlePhytochemical profile and some biological activities of three Centaurea species from Turkeyen_US
dc.titlePhytochemical profile and some biological activities of three Centaurea species from Turkey
dc.typeArticleen_US

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