Immunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate

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dc.contributor.authorSula, Bilal
dc.contributor.authorDeveci, Engin
dc.contributor.authorOzevren, Huseyin
dc.contributor.authorEkinci, Cenap
dc.contributor.authorElbey, Bilal
dc.date.accessioned2024-04-24T17:24:11Z
dc.date.available2024-04-24T17:24:11Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractLead acetate is a chemical compound. Sources of human exposure to this metal include many foods, drinking water and dust. The aim of this study was to determine the immunohistochemical and histopathological changes on the face skin after lead acetate application. Wistar Albino rats (180-200 g body weight) were divided into a controlled and lead acetate-exposed group. Rats received lead acetate at 500 ppm in their drinking water for 60 days. Both groups were fed with the same standard food, but lead acetate was added to the drinking water. During the experimental period, blood samples were drawn from the abdominal aorta of the anesthetised animals. At the end of exposure, body weight and blood lead levels were measured. Sections of rat facial skin were examined histopathological and immunohistochemical. In the group treated with lead acetate, minimal to slight multifocal hydropic degeneration of basal cell layer, depending on the thinning of the epidermis, the cellular degeneration in the dermis and a increase in the number of necrotic cells was observed in sebaceous glands of the hair follicle hemorrhage. The immunohistochemical results of the present work demonstrated an increase in Proliferating cell nuclear antigen (PCNA) immunoreactivity in skin specimens from lead acetate treated animals. Vimentin immunoreactivity was very dense in hair follicle of the subepidermal region. It was also strongly stained around the myoepithelial cells surrounding sebaceous and stromal cells.en_US
dc.identifier.doi10.4067/S0717-95022016000300017
dc.identifier.endpage922en_US
dc.identifier.issn0717-9502
dc.identifier.issn0717-9367
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84994431073
dc.identifier.scopusqualityQ3
dc.identifier.startpage918en_US
dc.identifier.urihttps://doi.org/10.4067/S0717-95022016000300017
dc.identifier.urihttps://hdl.handle.net/11468/19493
dc.identifier.volume34en_US
dc.identifier.wosWOS:000387656400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal of Morphology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLead Acetateen_US
dc.subjectSkinen_US
dc.subjectProliferating Cell Nuclear Antigenen_US
dc.subjectVimentinen_US
dc.titleImmunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetateen_US
dc.titleImmunohistochemical and Histopathological Changes in the Skin of Rats after Administration of Lead Acetate
dc.typeArticleen_US

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