Expression of Beta Human Chorionic Gonadotropin in the Placenta of Gestational Diabetic Mothers An Immunohistochemistry and Ultrastructural Study

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dc.contributor.authorSak, Muhammed Erdal
dc.contributor.authorDeveci, Engin
dc.contributor.authorEvsen, Mehmet Siddik
dc.contributor.authorKalkanli, Sevgi
dc.contributor.authorBaran, Ozlem
dc.contributor.authorOzekinci, Selver
dc.contributor.authorSeker, Ugur
dc.date.accessioned2024-04-24T17:40:22Z
dc.date.available2024-04-24T17:40:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate morphologic differences of the placenta in pregnancies complicated by gestational diabetes compared to nondiabetic pregnancies. STUDY DESIGN: This was a comparative morphological study of the placentas from 20 women with gestational diabetes and 20 healthy pregnancies at 28-35 weeks of gestation. RESULTS: The presence of lesions such as fibrinoid necrosis, villous edema, syncytial knot and vascular lesions like chorangiosis was apparent, mainly in the diabetes group. There was an apparent decrease in the intensity of the human chorionic gonadotropin (hCG) immunostaining in the syncytiotrophoblast from the 28th to 35th weeks of gestation in the placentas of the healthy control group. No hCG immunostaining was observed in the vinous or intervillous areas of any of the placentas. In diabetic placentas the expression of hCG was homogeneous with a moderate to intense immunoreactivity in the syncytiotrophoblast. Several syncytiotrophoblast cells showed dilations of both rough and smooth endoplasmic reticulum and loss and alteration of microvilli, and large vacuoles were observed just below the plasma membrane, as well as irregularities in the mitochondria. CONCLUSION: Syncytial cells play an important role in the placental transition. Increased expression of beta-hCG, deterioration, degeneration of organelles and cell structure and the basal membrane disorder in chorionic vessels were seen in placentas with gestational diabetes. These changes can affect placental transfer. However, further studies are needed to clarify this issue. (Anal Quant Cytopathol Histopathol 2013;35:52-56)en_US
dc.identifier.endpage56en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.pmid23469624
dc.identifier.startpage52en_US
dc.identifier.urihttps://hdl.handle.net/11468/21766
dc.identifier.volume35en_US
dc.identifier.wosWOS:000315010300007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytology and Histology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBeta Hcgen_US
dc.subjectDiabetes Mellitus, Gestationalen_US
dc.subjectGestational Diabetesen_US
dc.subjectHcg-Betaen_US
dc.subjectPlacentaen_US
dc.titleExpression of Beta Human Chorionic Gonadotropin in the Placenta of Gestational Diabetic Mothers An Immunohistochemistry and Ultrastructural Studyen_US
dc.titleExpression of Beta Human Chorionic Gonadotropin in the Placenta of Gestational Diabetic Mothers An Immunohistochemistry and Ultrastructural Study
dc.typeArticleen_US

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