Neuroprotective Effects of Potentilla Fulgens on Traumatic Brain Injury in Rats

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dc.contributor.authorOzevren, Huseyin
dc.contributor.authorIrtegun, Sevgi
dc.contributor.authorDeveci, Engin
dc.contributor.authorOzgur, Mustafa Esref
dc.contributor.authorAsir, Firat
dc.contributor.authorTekin, Mehmet Ali
dc.contributor.authorDeveci, Senay
dc.date.accessioned2024-04-24T17:47:41Z
dc.date.available2024-04-24T17:47:41Z
dc.date.issued2017
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate if Potentilla fulgens (P. fulgens) has any neuroprotective effects on traumatic brain injury in rats. STUDY DESIGN: Sprague-Dawley rats were subjected to traumatic brain injury with a weight-drop device using 300 g(-1) m weight-height impact. Sixty-four rats were divided into 4 groups: group 1 (vehicle-treated control), group 2 (P. fulgens 400 mg/kg/day, intraperitoneally [i.p.]), group 3 (vehicle-treated trauma), and group 4 (trauma+P. fulgens 400 mg/kg/day, i.p.). Distilled water was used as vehicle. All rats were decapitated 5 days after the induction of trauma, and the protective effects of P. fulgens were evaluated by histological, immunohistochemical, and biochemical analyses. RESULTS: Administration of P. fulgens at a dose of 400 mg/kg/day provided significant improvement in all of the histological, biochemical, and immunohistochemical analyses after the induction of traumatic brain injury. CONCLUSION: Although further studies are necessary to evaluate the time-and dose-dependent neuroprotective effects of P. fulgens, it may be a beneficial therapeutic agent for prevention of secondary neuronal damage following diffuse traumatic brain injury.en_US
dc.identifier.endpage44en_US
dc.identifier.issn0884-6812
dc.identifier.issue1en_US
dc.identifier.startpage35en_US
dc.identifier.urihttps://hdl.handle.net/11468/22686
dc.identifier.volume39en_US
dc.identifier.wosWOS:000398130900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCinquefoilen_US
dc.subjectCraniocerebral Injuriesen_US
dc.subjectHead Injuryen_US
dc.subjectHead Traumaen_US
dc.subjectPotentillaen_US
dc.subjectPotentilla Fulgensen_US
dc.subjectRats, Laboratoryen_US
dc.subjectSilverweeden_US
dc.subjectTraumatic Brain Injuryen_US
dc.subjectTraumatic Encephalopathyen_US
dc.titleNeuroprotective Effects of Potentilla Fulgens on Traumatic Brain Injury in Ratsen_US
dc.typeArticleen_US

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